Water-soluble fluorescent unimolecular micelles: ultra-small size, tunable fluorescence emission from the visible to NIR region and enhanced biocompatibility for in vitro and in vivo bioimaging†,Chemical Communications

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Water-soluble fluorescent unimolecular micelles: ultra-small size, tunable fluorescence emission from the visible to NIR region and enhanced biocompatibility for in vitro and in vivo bioimaging†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-04-30 00:00:00 , DOI: 10.1039/c8cc02261e
Xiaoqian Ma _{1,

2,

3,

4,

5} , Xiaoxiao Shi _{1,

2,

3,

4,

5} , Shuang Bai _{1,

2,

3,

4,

5} , Jianjian Zhang _{5,

6,

7,

8,

9} , Meili Hou _{1,

2,

3,

4,

5} , Tian Zhang _{1,

2,

3,

4,

5} , Bao-sheng Li _{5,

10,

11,

12} , Peng Xue _{1,

2,

3,

4,

5} , Yuejun Kang _{1,

2,

3,

4,

5} , Zhigang Xu _{1,

2,

3,

4,

5}

Affiliation

Fluorescent unimolecular micelles (FUMs) with multicolor emission acting as fluorescent nanoagents for optical fluorescence imaging have, for the first time, been reported. The FUMs show good water-solubility, ultra-small size, and enhanced biocompatibility, which endow the FUMs with versatile applications including organelle labeling, multicolor markers and high tumor accumulation, revealing that our design can serve as a rational strategy for the development of UM-based fluorescent nanoagents for bioprocess monitoring.

中文翻译：

水溶性荧光单分子胶束：超小尺寸，从可见光到NIR区域可调节的荧光发射，并增强了体内和体外生物成像的生物相容性†

首次报道了具有多色发射的荧光单分子胶束（FUM），用作光学荧光成像的荧光纳米剂。FUM具有良好的水溶性，超小尺寸和增强的生物相容性，这赋予了FUM多种用途，包括细胞器标记，多色标记和高肿瘤积累，这表明我们的设计可以作为UM发展的合理策略。基荧光纳米剂用于生物过程监控。

更新日期：2018-04-30

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