Strategies to Overcome the Limitations of AIEgens in Biomedical Applications,Small Methods

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Strategies to Overcome the Limitations of AIEgens in Biomedical Applications
Small Methods ( IF 10.7 ) Pub Date : 2018-04-30 , DOI: 10.1002/smtd.201700392
Bobo Gu _{1,

2} , Ken-Tye Yong ₂ , Bin Liu ₃

Affiliation

Motivated by the demand for high‐performance tools for biomedical applications, numerous new luminescent nanomaterials with advanced functionalities are synthesized in recent years. Conventional fluorophores generally suffer from the notorious aggregation‐caused quenching effect that deteriorates their practical performance. The recently emerged fluorogens with aggregation‐induced emission (AIE) characteristics (AIEgen) have generated a new avenue for biomedical applications due to their unique optical properties, flexible designability, and multifunctional potential. However, the inherent characteristics of AIEgens, including short wavelength absorption, broad emission, and aggregation‐dependent brightness indirectly limit their practical performance in the biomedical field. Here, the recent development of AIEgens for biomedical applications is summarized and novel strategies to overcome their limitations are proposed. Furthermore, the strategies and guidelines for the rational design of AIEgens, preparation of water‐dispersible AIE nanoparticles, and selection of the excitation/emission methods, which enable AIEgens to be useful in a broader range of biomedical applications, are discussed.

中文翻译：

克服生物医学应用中AIEgens局限性的策略

由于对生物医学应用高性能工具的需求，近年来合成了许多具有先进功能的新型发光纳米材料。常规荧光团通常会因臭名昭著的聚集引起的猝灭作用而受苦，这会降低其实际性能。具有聚集诱导发射（AIEgen）特性的最新出现的氟气（AIEgen）凭借其独特的光学性能，灵活的设计能力和多功能潜力，为生物医学应用开辟了一条新途径。但是，AIEgens的固有特性（包括短波长吸收，宽发射和依赖聚集的亮度）间接限制了它们在生物医学领域的实际性能。这里，总结了用于生物医学应用的AIEgens的最新发展，并提出了克服其局限性的新策略。此外，还讨论了合理设计AIEgens，制备水分散性AIE纳米颗粒以及选择激发/发射方法的策略和指南，这些方法和指南使AIEgens可以在更广泛的生物医学应用中使用。

更新日期：2018-04-30

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