Recent Advances in Polyanhydride Based Biomaterials,Advanced Materials

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Recent Advances in Polyanhydride Based Biomaterials
Advanced Materials ( IF 27.4 ) Pub Date : 2018-04-30 , DOI: 10.1002/adma.201706815
Arijit Basu _{1,

2} , Abraham J. Domb ₁

Affiliation

This review focusses on recent developments of polyanhydrides, a class of degradable synthetic biopolymers. Polyanhydrides have been used as carriers for controlled delivery of drugs. A polyanhydride copolymer of carboxyphenoxy propane and sebacic acid has been used in Gliadel brain tumor implants for the controlled delivery of carmustine or bis‐chloroethylnitrosourea. They are easy and inexpensive to synthesize (especially scale up). However, polyanhydrides possess a short shelf‐life. Hydrolytic cleavage and anhydride interchanges lower their molecular weights during storage. One of the highlights in recent developments of polyanhydride chemistry is the discovery of alternating copolymers having extended shelf‐life. Other highlights include their applications in biomedical electronics, vaccine delivery, and nano/micro particulate delivery systems. This review examines approaches for polyanhydride synthesis followed by their recent developments in biomedical applications.

中文翻译：

聚酸酐基生物材料的最新进展

这篇综述着重于聚酸酐的最新进展，聚酸酐是一类可降解的合成生物聚合物。聚酸酐已被用作载体以控制药物的输送。羧苯氧基丙烷和癸二酸的聚酸酐共聚物已被用于Gliadel脑肿瘤植入物中，用于控制卡马汀或双氯乙基亚硝基脲的递送。它们易于合成且成本低廉（尤其是按比例放大）。但是，聚酸酐的保质期很短。水解裂解和酸酐互换降低了其在存储过程中的分子量。聚酸酐化学近来发展的一大亮点是发现具有延长保存期限的交替共聚物。其他亮点包括它们在生物医学电子，疫苗输送和纳米/微粒输送系统中的应用。

更新日期：2018-04-30

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