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Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-27 , DOI: 10.1002/adhm.201701392 Peiyan Yuan 1 , Xin Ding 2 , Yi Yan Yang 2 , Qing-Hua Xu 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-27 , DOI: 10.1002/adhm.201701392 Peiyan Yuan 1 , Xin Ding 2 , Yi Yan Yang 2 , Qing-Hua Xu 1
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Infectious diseases caused by pathogenic bacteria, especially multidrug‐resistant bacteria, and their global spreading have become serious public health concerns. Early diagnosis and effective therapy can efficiently prevent deterioration and further spreading of the infections. There is an urgent need for sensitive, selective, and facile diagnosis as well as therapeutically potent treatment. The emergence of nanotechnology has provided more options for diagnosis and treatments of bacterial infections. Metal nanoparticles and metal oxide nanoparticles have drawn intense attention owing to their unique optical, magnetic, and electrical properties. These versatile metal‐based nanoparticles have great potential for selective detection of bacteria and/or therapy. This review gives an overview of recent efforts on developing various metal‐based nanoparticles for bacterial detection and infection therapy. It begins with an introduction of fundamental concepts and mechanisms in designing diagnostic and therapeutic strategies. Representative achievements are selected to illustrate the proof‐of‐concept in vitro and in vivo applications. A brief discussion of challenges and perspective outlook in this field is provided at the end of this review.
中文翻译：
金属纳米颗粒用于细菌感染的诊断和治疗
由病原菌（尤其是耐多药细菌）引起的传染病及其在全球的传播已成为严重的公共卫生问题。早期诊断和有效治疗可以有效地预防感染的恶化和进一步扩散。迫切需要灵敏，选择性和简便的诊断以及有效的治疗方法。纳米技术的出现为细菌感染的诊断和治疗提供了更多的选择。金属纳米颗粒和金属氧化物纳米颗粒由于其独特的光学，磁性和电学性质而受到了广泛的关注。这些多用途的基于金属的纳米颗粒具有选择性检测细菌和/或治疗的巨大潜力。这篇综述概述了最近为开发用于细菌检测和感染治疗的各种金属基纳米颗粒所做的努力。它从介绍设计诊断和治疗策略的基本概念和机制开始。选择具有代表性的成就来说明体外和体内应用的概念验证。这篇评论的结尾部分简要讨论了该领域的挑战和前景。
更新日期：2018-03-27
中文翻译：
金属纳米颗粒用于细菌感染的诊断和治疗
由病原菌（尤其是耐多药细菌）引起的传染病及其在全球的传播已成为严重的公共卫生问题。早期诊断和有效治疗可以有效地预防感染的恶化和进一步扩散。迫切需要灵敏，选择性和简便的诊断以及有效的治疗方法。纳米技术的出现为细菌感染的诊断和治疗提供了更多的选择。金属纳米颗粒和金属氧化物纳米颗粒由于其独特的光学，磁性和电学性质而受到了广泛的关注。这些多用途的基于金属的纳米颗粒具有选择性检测细菌和/或治疗的巨大潜力。这篇综述概述了最近为开发用于细菌检测和感染治疗的各种金属基纳米颗粒所做的努力。它从介绍设计诊断和治疗策略的基本概念和机制开始。选择具有代表性的成就来说明体外和体内应用的概念验证。这篇评论的结尾部分简要讨论了该领域的挑战和前景。
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