Nitric oxide (NO) levels in exhaled breath are a non-invasive marker that can be used to diagnose various respiratory diseases and monitor a patient's response to given therapies. A portable and inexpensive device that can enable selective NO concentration measurements in exhaled breath samples is needed. Herein, the performance of an amperometric Pt-Nafion-based gas phase sensor for detection of NO in exhaled human nasal breath is examined. Enhanced selectivity over carbon monoxide and ammonia is achieved via an in-line zinc oxide-based filter. Exhaled nasal NO levels measured in 21 human samples with the sensor are shown to correlate well with those obtained using a chemiluminescence reference method (R2 = 0.9836).

中文翻译：

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用于测定人鼻呼出气体中一氧化氮 (NO) 水平的安培铂化 Nafion 气相传感器的性能

呼出气中的一氧化氮 (NO) 水平是一种非侵入性标记物，可用于诊断各种呼吸系统疾病并监测患者对特定治疗的反应。需要一种便携式且廉价的设备，可以选择性测量呼出气样本中的一氧化氮浓度。在此，检查了基于 Pt-Nafion 的电流型气相传感器检测人类鼻呼出气体中 NO 的性能。通过在线氧化锌过滤器可提高对一氧化碳和氨的选择性。使用传感器在 21 个人体样本中测量的呼出鼻 NO 水平与使用化学发光参考方法获得的水平具有良好的相关性（R2 = 0.9836）。