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Mesoporous Bimetallic PtPd Nanoflowers as a Platform to Enhance Electrocatalytic Activity of Acetylcholinesterase for Organophosphate Pesticide Detection
Electroanalysis ( IF 2.7 ) Pub Date : 2018-04-18 , DOI: 10.1002/elan.201700845
Li Ma 1 , Liya Zhou 1 , Ying He 1 , Lihui Wang 1 , Zhihong Huang 1 , Yanjun Jiang 1, 2 , Jing Gao 1
Affiliation  

Mesoporous bimetallic PtPd nanoflowers (MPtPdN) were synthesized by a surfactant‐directing method. The MPtPdN was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and wide‐angle X‐ray diffraction (XRD). The use of MPtPdN as a platform for the indirect electrochemical detection of organophosphate pesticides (OPs) via enzymatic inhibition pathway was demonstrated. Due to the nanostructure of MPtPdN and the synergy effect of the noble metal nanoparticles, a novel and sensitive acetylcholinesterase (AChE) biosensor for OPs detections based on MPtPdN and enzyme inhibition was prepared. The inhibition of omethoate exhibited a linear relationship from 4.7×10−11 to 4.7×10−8 M with a detection limit of 1.7×10−12 M (S/N=3). The proposed AChE biosensor was reliable and can be used to measure the concentration of omethoate in different spiked samples with high accuracy and satisfactory recovery. The preparation of biosensors based on the MPtPdN can be further extended to construct many other important enzyme biosensors.

中文翻译:

介孔双金属PtPd纳米花为平台,以增强乙酰胆碱酯酶对有机磷酸酯农药检测的电催化活性

介孔双金属PtPd纳米花(MPtPdN)是通过表面活性剂定向方法合成的。MPtPdN的特征在于扫描电子显微镜(SEM),透射电子显微镜(TEM)和广角X射线衍射(XRD)。证明了使用MPtPdN作为通过酶抑制途径间接电化学检测有机磷酸酯农药(OPs)的平台。鉴于MPtPdN的纳米结构和贵金属纳米粒子的协同作用,制备了一种新颖且灵敏的基于MPtPdN和酶抑制作用的OPs检测的乙酰胆碱酯酶(AChE)生物传感器。氧化乐果的抑制表现出从4.7×10 -11到4.7×10 -8  M的线性关系,检出限为1.7×10 -12 M(S / N = 3)。所提出的AChE生物传感器是可靠的,可用于高精度地测量令人满意的加标样品中氧化乐果的浓度。基于MPtPdN的生物传感器的制备可以进一步扩展以构建许多其他重要的酶生物传感器。
更新日期:2018-04-18
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