The front cover shows translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) enhancer to the nuclei that was induced by its novel enhancer: 1‐(4‐((3,4‐dihydroxybenzylidene)amino)phenyl)‐5‐oxopyrrolidine‐3‐carboxylic acid. This compound showed potent antioxidant properties through activation of genes related to antioxidative cellular response. Details are given in the Full Paper by Arie Gruzman and co‐workers on page 320 in Issue 5, 2018 (DOI: 10.1002/cplu.201700539).

中文翻译：

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封面：1-N-f4增强剂1- {4-[（（3,4-二羟基亚苄基）氨基]苯基} -5-氧吡咯烷-3-羧酸的计算机辅助设计和合成（ChemPlusChem 5/2018）

封面显示了核因子红系2相关因子2（Nrf2）增强子向其新增强子诱导的核易位：1-（4-（（3,4-二羟基苄叉基）氨基）苯基）-5-氧代吡咯烷-3-羧酸 该化合物通过激活与抗氧化细胞反应有关的基因而显示出有效的抗氧化特性。有关详细信息，请参见Arie Gruzman及其同事在2018年第5期第320页上的全文（DOI：10.1002 / cplu.201700539）。