Front Cover Picture: Silicon‐based Bulky Group−Tuned Parallel Kinetic Resolution in Copper‐Catalyzed 1,3‐Dipolar Additions (Adv. Synth. Catal. 16/2018),Advanced Synthesis & Catalysis

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Front Cover Picture: Silicon‐based Bulky Group−Tuned Parallel Kinetic Resolution in Copper‐Catalyzed 1,3‐Dipolar Additions (Adv. Synth. Catal. 16/2018)
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-04-27 , DOI: 10.1002/adsc.201800502
Yang Yuan ₁ , Zhan-Jiang Zheng ₁ , Li Li ₁ , Xing-Feng Bai _{1,

2} , Zheng Xu ₁ , Yu-Ming Cui ₁ , Jian Cao ₁ , Ke-Fang Yang ₁ , Li-Wen Xu _{1,

2}

Affiliation

The front cover picture, designed by Yang Yuan from the group of Li‐Wen Xu, illustrates how their silicon mediates organic synthesis (SiMOS). The silicon‐based bulky group enables a 1,3‐dipolar addition‐initiated parallel kinetic resolution (PKR) to occur unexpectedly, leading to the highly enantioselective synthesis of two structurally different types of amino acid derivatives with high optical purity (up to 99% ee) via [3+2] cycloaddition reactions and tandem conjugate addition‐elimination reactions, respectively. Details can be found in the communication on pages 3002–3008 (Y. Yuan, Z.‐J. Zheng, L. Li, X.‐F. Bai, Z. Xu, Y.‐M. Cui, J. Cao, K.‐F. Yang, L.‐W. Xu, Adv. Synth. Catal. 2018, 360, 3002–3008; DOI: 10.1002/adsc.201800220).

中文翻译：

封面图片：铜催化的1,3-偶极加成物中基于硅的大基团调整的并行动力学拆分（Adv。Synth。Catal.16 / 2018）

由Li Li-Wen Xu组的Yang Yuan设计的封面图片说明了它们的硅如何介导有机合成（SiMOS）。硅基庞大的基团使1,3偶极加成引发的平行动力学拆分（PKR）意外发生，从而导致了两种结构不同类型的氨基酸衍生物的高度对映选择性合成，具有较高的光学纯度（高达99％ee）分别通过[3 + 2]环加成反应和串联共轭加成消除反应。有关详细信息，请参见第3002–3008页的通讯（Y. Yuan，Z.-J. Zheng，L. Li，X.-F. Bai，Xu Z.Xu，C.，M. Cui，Ca. J. K.-F.杨，徐L.-W.，进阶合成器。CATAL。2018，360，3002–3008; DOI：10.1002 / adsc.201800220）。

更新日期：2018-04-27

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