Self-Assembly of Polyoxometalate-Peptide Hybrids in Solution - Elucidating the Contributions of Multiple Possible Driving Forces,European Journal of Inorganic Chemistry

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Self-Assembly of Polyoxometalate-Peptide Hybrids in Solution - Elucidating the Contributions of Multiple Possible Driving Forces
European Journal of Inorganic Chemistry ( IF 2.2 ) Pub Date : 2018-05-14 , DOI: 10.1002/ejic.201800158
Jiancheng Luo ₁ , Baofang Zhang ₁ , Carine Yvon ₂ , Marie Hutin ₂ , Selim Gerislioglu ₃ , Chrys Wesdemiotis ₃ , Leroy Cronin ₂ , Tianbo Liu ₁

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Incorporating the building blocks of nature (e.g., peptides and DNA) into inorganic polyoxometalate (POM) clusters is a promising approach to improve the compatibilities of POMs in biological fields. To extend their biological applications, it is necessary to understand the importance of different non‐covalent interactions during self‐organization. A series of Anderson POM–peptide hybrids have been used as a simple model to demonstrate the role of different interactions in POM–peptide (biomolecules) systems. Regardless of peptide chain length, these hybrids follow similar solution behaviors, forming hollow, spherical supramolecular structures in acetonitrile/water mixed solvents. The incorporation of peptide tails introduces interesting stimuli‐responsive properties to temperature, hybrid concentration, solvent polarity and ionic strength. Unlike the typical bilayer amphiphilic vesicles, they are found to follow the blackberry‐type assemblies of hydrophilic macroions, which are regulated by electrostatic interaction and hydrogen bonding. The formation of electrostatic assemblies before the supramolecular formation is confirmed by ion‐mobility mass spectrometry (IMS‐MS).

中文翻译：

溶液中多金属氧酸盐-肽杂化物的自组装——阐明多种可能驱动力的贡献

将自然界的组成部分（例如，肽和 DNA）结合到无机多金属氧酸盐 (POM) 簇中是提高 POM 在生物领域中的相容性的一种有前途的方法。为了扩展它们的生物学应用，有必要了解自组织过程中不同非共价相互作用的重要性。一系列安德森 POM-肽杂交体已被用作一个简单的模型来证明不同相互作用在 POM-肽（生物分子）系统中的作用。无论肽链长度如何，这些杂交体都遵循相似的溶液行为，在乙腈/水混合溶剂中形成中空的球形超分子结构。肽尾的结合引入了对温度、杂化浓度、溶剂极性和离子强度的有趣刺激响应特性。与典型的双层两亲性囊泡不同，发现它们遵循黑莓型亲水大离子组装，由静电相互作用和氢键调节。在超分子形成之前，静电组装的形成通过离子迁移质谱法 (IMS-MS) 得到证实。

更新日期：2018-05-14

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