Large‐Scale Synthesis and Medical Applications of Uniform‐Sized Metal Oxide Nanoparticles,Advanced Materials

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Large‐Scale Synthesis and Medical Applications of Uniform‐Sized Metal Oxide Nanoparticles
Advanced Materials ( IF 27.4 ) Pub Date : 2018-03-24 , DOI: 10.1002/adma.201704290
Hyek Jin Kwon _{1,

2} , Kwangsoo Shin _{1,

2} , Min Soh _{1,

2} , Hogeun Chang _{1,

2} , Jonghoon Kim _{1,

2} , Jisoo Lee _{1,

2} , Giho Ko _{1,

2} , Byung Hyo Kim ₁ , Dokyoon Kim ₁ , Taeghwan Hyeon _{1,

2}

Affiliation

Thanks to recent advances in the synthesis of high‐quality inorganic nanoparticles, more and more types of nanoparticles are becoming available for medical applications. Especially, metal oxide nanoparticles have drawn much attention due to their unique physicochemical properties and relatively inexpensive production costs. To further promote the development and clinical translation of these nanoparticle‐based agents, however, it is highly desirable to reduce unwanted interbatch variations of the nanoparticles because characterizing and refining each batch are costly, take a lot of effort, and, thus, are not productive. Large‐scale synthesis is a straightforward and economic pathway to minimize this issue. Here, the recent achievements in the large‐scale synthesis of uniform‐sized metal oxide nanoparticles and their biomedical applications are summarized, with a focus on nanoparticles of transition metal oxides and lanthanide oxides, and clarifying the underlying mechanism for the synthesis of uniform‐sized nanoparticles. Surface modification steps to endow hydrophobic nanoparticles with water dispersibility and biocompatibility are also briefly described. Finally, various medical applications of metal oxide nanoparticles, such as bioimaging, drug delivery, and therapy, are presented.

中文翻译：

均相金属氧化物纳米粒子的大规模合成及医学应用

得益于高质量无机纳米颗粒合成的最新进展，越来越多类型的纳米颗粒可用于医疗应用。特别地，金属氧化物纳米颗粒由于其独特的物理化学性质和相对便宜的生产成本而备受关注。但是，为了进一步促进这些基于纳米颗粒的试剂的开发和临床翻译，非常需要减少纳米颗粒之间不希望出现的批间差异，因为表征和精制每批都是昂贵的，需要大量的工作，因此不是富有成效的。大规模合成是将这一问题最小化的直接且经济的途径。这里，总结了均匀尺寸金属氧化物纳米颗粒的大规模合成及其生物医学应用的最新进展，重点是过渡金属氧化物和镧系元素氧化物的纳米颗粒，并阐明了均匀尺寸纳米颗粒合成的基本机理。还简要描述了赋予疏水性纳米颗粒水分散性和生物相容性的表面改性步骤。最后，介绍了金属氧化物纳米粒子的各种医学应用，例如生物成像，药物输送和治疗。还简要描述了赋予疏水性纳米颗粒水分散性和生物相容性的表面改性步骤。最后，介绍了金属氧化物纳米粒子的各种医学应用，例如生物成像，药物输送和治疗。还简要描述了赋予疏水性纳米颗粒水分散性和生物相容性的表面改性步骤。最后，介绍了金属氧化物纳米粒子的各种医学应用，例如生物成像，药物输送和治疗。

更新日期：2018-03-24

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