当前位置：
X-MOL 学术
›
J. Nat. Prod.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Poecillastrin H, a Chondropsin-Type Macrolide with a Conjugated Pentaene Moiety, from a Characella sp. Marine Sponge
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-04-27 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00180 Rei Suo 1 , Kentaro Takada 1 , Raku Irie 1 , Ryuichi Watanabe 2 , Toshiyuki Suzuki 2 , Yuji Ise 3 , Susumu Ohtsuka 4 , Shigeru Okada 1 , Shigeki Matsunaga 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-04-27 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00180 Rei Suo 1 , Kentaro Takada 1 , Raku Irie 1 , Ryuichi Watanabe 2 , Toshiyuki Suzuki 2 , Yuji Ise 3 , Susumu Ohtsuka 4 , Shigeru Okada 1 , Shigeki Matsunaga 1
Affiliation
|
Poecillastrin H (1), a chondropsin-type macrolide with a conjugated pentaene moiety, was isolated from the Characella sp. marine sponge. The planar structure of 1 was elucidated by analysis of spectroscopic data. The absolute configuration of the β-hydroxyaspartic acid residue (β-OHAsp) was determined to be d-threo by Marfey’s analysis, and the mode of lactone ring formation through the OHAsp residue was determined by chemical degradation. Poecillastrin H was extremely sensitive toward light and showed potent cytotoxic activity against 3Y1 cells with an IC50 value of 4.1 nM.
中文翻译：
Poecillastrin H，一种软骨素型大环内酯，具有共轭戊烯部分，来自Characella sp.。海洋海绵
从Characella sp。中分离出Poecillastrin H（1），一种具有共轭戊烯部分的软骨素型大环内酯。海洋海绵。通过光谱数据分析来阐明1的平面结构。测定β羟基天冬氨酸残基的绝对构型（β-OHAsp）是d -苏通过的Marfey的分析，和内酯环的形成通过OHAsp残余模式用化学降解法测定。Poecillastrin H对光极为敏感，对3Y1细胞表现出强大的细胞毒活性，IC 50值为4.1 nM。
更新日期：2018-04-27
中文翻译：
Poecillastrin H，一种软骨素型大环内酯，具有共轭戊烯部分，来自Characella sp.。海洋海绵
从Characella sp。中分离出Poecillastrin H（1），一种具有共轭戊烯部分的软骨素型大环内酯。海洋海绵。通过光谱数据分析来阐明1的平面结构。测定β羟基天冬氨酸残基的绝对构型（β-OHAsp）是d -苏通过的Marfey的分析，和内酯环的形成通过OHAsp残余模式用化学降解法测定。Poecillastrin H对光极为敏感，对3Y1细胞表现出强大的细胞毒活性，IC 50值为4.1 nM。
京公网安备 11010802027423号