Abstract Sequence-defined and information coding macromolecules suitable for data storage materials were synthesized via a combination of two multicomponent reactions. Thus, a well-established protocol based on the Passerini reaction was combined for the first time with the Biginelli reaction for monomer synthesis to explore new sequence-defined materials by exploiting the high structural variety of two multicomponent reactions. The information was encoded via the variation of six different components per repeating unit choosing from a list of more than 100 components that can potentially be applied. The structural variety of the oligomers that can achieved using this approach offers an information density of up to 24 bits per repeat unit. The information was read out via tandem mass spectrometry, wherein the predominant fragmentation processes were identified and subsequently applied for reading out the information contained within several macromolecules, i.e. by sequencing and re-establishing the structure of these macromolecules.

中文翻译：

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通过多组分反应在序列定义的大分子中存储数据

摘要 通过两种多组分反应的组合，合成了适用于数据存储材料的序列定义和信息编码大分子。因此，首次将基于 Passerini 反应的完善方案与 Biginelli 反应结合用于单体合成，通过利用两种多组分反应的高结构多样性来探索新的序列定义材料。该信息是通过从 100 多个可能应用的组件列表中选择的每个重复单元的六个不同组件的变化进行编码的。使用这种方法可以获得的低聚物的结构多样性提供了每个重复单元高达 24 位的信息密度。通过串联质谱法读出信息，