Palladium‐Catalyzed C−H Iodination of N‐(8‐Quinolinyl)benzamide Derivatives Under Electrochemical and Non‐Electrochemical Conditions,Asian Journal of Organic Chemistry

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Palladium‐Catalyzed C−H Iodination of N‐(8‐Quinolinyl)benzamide Derivatives Under Electrochemical and Non‐Electrochemical Conditions
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-05-09 , DOI: 10.1002/ajoc.201800202
Katsuya Sano ₁ , Naoki Kimura ₁ , Takuya Kochi ₁ , Fumitoshi Kakiuchi ₁

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Palladium‐catalyzed ortho‐selective C−H iodination of N‐(8‐quinolinyl)benzamides proceeded using I₂ under both electrochemical and non‐electrochemical conditions. The C−H iodination at 90 °C under base‐free conditions provided high yields of the iodination products. The use of anodic oxidation increased the efficiency of the iodination at sterically‐hindered positions.

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