Acute myocardial infarction (AMI) is a main threat to human lives worldwide. Early and accurate diagnoses warrant immediate medical care, which would reduce mortality and improve prognoses. Circulating non-coding RNAs have been demonstrated to serve as competent biomarkers for various diseases. Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction. Here, we summarized recent findings on non-coding RNAs as biomarkers for early diagnosis of ST-segment elevation myocardial infarction and for disease monitoring of myocardial infarction. In addition, the prognostic potential of non-coding RNAs in patients treated with percutaneous coronary intervention was also described. We also include studies based on biobanks, and build a miRNA release spectrum after AMI, which provides quantitative and time-lapse monitoring of AMI progress. With this spectrum, we are able to customize personal medical care, which prevents further damage. By constructing a network of circulating non-coding RNAs with high specificity and sensitivity, detailed diagnostic information was provided for personalized medicine. Unveiling the roles and kinetics of circulating non-coding RNAs may lead to a revolution in clinical diagnosis.

中文翻译：

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非编码RNA作为急性心肌梗死的生物标志物。

急性心肌梗塞（AMI）是全世界人类生命的主要威胁。早期和准确的诊断需要立即进行医疗护理，这将降低死亡率并改善预后。循环非编码RNA已被证明可以作为各种疾病的有效生物标志物。在鉴定出循环中的心脏特异性microRNA miR-208a之后，更多的非编码RNA（miR-1，miR-499和miR-133）已被鉴定为生物标志物，不仅可用于AMI的诊断，还可用于梗塞后的预后。在这里，我们总结了关于非编码RNAs的最新发现，这些RNAs是用于ST段抬高型心肌梗死的早期诊断和心肌梗塞疾病监测的生物标记物。此外，还描述了非编码RNA在经皮冠状动脉介入治疗患者中的预后潜力。我们还包括基于生物库的研究，并建立了AMI后的miRNA释放谱，从而提供了对AMI进展的定量和延时监测。有了这个频谱，我们能够定制个人医疗保健，从而防止进一步的损害。通过构建具有高度特异性和敏感性的循环非编码RNA网络，为个性化医学提供了详细的诊断信息。揭示循环非编码RNA的作用和动力学可能会导致临床诊断的一场革命。我们能够定制个人医疗服务，以防止进一步的损害。通过构建具有高度特异性和敏感性的循环非编码RNA网络，为个性化医学提供了详细的诊断信息。揭示循环非编码RNA的作用和动力学可能会导致临床诊断的一场革命。我们能够定制个人医疗服务，以防止进一步的损害。通过构建具有高度特异性和敏感性的循环非编码RNA网络，为个性化医学提供了详细的诊断信息。揭示循环非编码RNA的作用和动力学可能会导致临床诊断的一场革命。