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Synthesis and cytotoxic activities of difluoroacetyl-substituted hexahydropyrimidine derivatives
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2018-04-22 Natalya N. Gibadullina, Dilara R. Latypova, Vener A. Vakhitov, Diana V. Khasanova, Liana F. Zainullina, Yulia V. Vakhitova, Aleksandr N. Lobov, Bogdan I. Ugrak, Yury V. Tomilov, Vladimir A. Dokichev
中文翻译:
二氟乙酰基取代的六氢嘧啶衍生物的合成及细胞毒活性
更新日期:2018-04-27
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2018-04-22 Natalya N. Gibadullina, Dilara R. Latypova, Vener A. Vakhitov, Diana V. Khasanova, Liana F. Zainullina, Yulia V. Vakhitova, Aleksandr N. Lobov, Bogdan I. Ugrak, Yury V. Tomilov, Vladimir A. Dokichev
A series of novel difluoroacetyl hexahydropyrimidine derivatives have been synthesized by reactions of ethyl 4,4-difluoroacetoacetate, 1,1-difluoropentane-2,4-dione and 1,1,5,5-tetrafluoropentane-2,4-dione with an aqueous formaldehyde solution and amino acid ester hydrochlorides under Mannich reaction conditions. The in vitro cytotoxic activity of fluorine-containing hexahydropyrimidine derivatives were determined in cancer (Jurkat and HepG2) and conditionally normal (HEK293) human cells.
中文翻译:
二氟乙酰基取代的六氢嘧啶衍生物的合成及细胞毒活性
通过4,4-二氟乙酰乙酸乙酯,1,1-二氟戊烷-2,4-二酮和1,1,5,5-四氟戊烷-2,4-二酮与水的反应合成了一系列新型的二氟乙酰基六氢嘧啶衍生物。甲醛溶液和氨基酸盐酸盐在曼尼希反应条件下。在体外含氟六氢嘧啶衍生物的细胞毒活性在癌症(Jurkat和HepG2细胞)和正常条件(HEK293)人细胞确定。