AbstractRecently, micro/nanofibrillar materials have been widely utilized for a variety of applications in many different fields of research due to their relatively large surface-to-volume ratios, high porosity, and three-dimensional connectivity, along with their cost-effective fabrication processes. Herein, we present a review of recent progress in the development of micro/nanofibrillar scaffolds with a specific focus on their biomedical applications. From the perspective of controlling polymer–polymer and polymer–water molecular interactions, we categorized the fibrillar scaffolds into insoluble, nanocrystalline, and hydrogel fibers. Based on our recent studies related to this research topic, we provide the significance and essential information on four different micro/nanofibrillar scaffolds: (1) solid micro/nanofibrillar scaffolds based on water-insoluble polymers, (2) hydrogel nanofibrillar network scaffolds based on crystalline bacterial cellulose, (3) hydrogel micro/nanofiber scaffolds based on partially precipitated PVA, and (4) hydrogel micro/nanofiber scaffolds based on chemically cross-linked PVA. The present discussion should provide guidance to researchers in selecting a micro/nanofibrillar scaffold suitable for their own purposes and should help inspire them to develop more sophisticated fibrillar scaffolds in the future.We reviewed the recent progress in the development of micro/nanofibrillar scaffolds for biomedical applications. We demonstrated the significance and essential information on four different micro/nanofibrillar scaffolds: (1) solid micro/nanofibrillar scaffolds (2) hydrogel nanofibrillar network scaffolds based on bacterial cellulose, (3) hydrogel micro/nanofiber scaffolds based on partially precipitated PVA, and (4) hydrogel micro/nanofiber scaffolds based on cross-linked PVA. This review would guide researchers for selecting a proper scaffold suitable for their own purposes and developing more sophisticated scaffolds.

中文翻译：

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用于生物医学应用的水不溶性纳米晶和水凝胶纤维支架

摘要 近年来，微/纳米原纤维材料由于其相对较大的表面积与体积比、高孔隙率和三维连通性以及成本效益高的制造工艺，已被广泛用于许多不同研究领域的各种应用。 . 在此，我们回顾了微/纳米纤维支架开发的最新进展，特别关注其生物医学应用。从控制聚合物-聚合物和聚合物-水分子相互作用的角度来看，我们将原纤维支架分为不溶性、纳米晶和水凝胶纤维。基于我们最近与该研究主题相关的研究，我们提供了四种不同微/纳米纤维支架的重要性和基本信息：(1) 基于水不溶性聚合物的固体微/纳米纤维支架，(2) 基于结晶细菌纤维素的水凝胶纳米纤维网络支架，(3) 基于部分沉淀 PVA 的水凝胶微/纳米纤维支架，和 (4) 水凝胶微/纳米纤维基于化学交联 PVA 的支架。目前的讨论应该为研究人员选择适合自己目的的微/纳米纤维支架提供指导，并有助于激发他们在未来开发更复杂的纤维支架。应用程序。我们展示了四种不同微/纳米纤维支架的重要性和基本信息：(1) 固体微/纳米纤维支架 (2) 基于细菌纤维素的水凝胶纳米纤维网络支架，(3) 基于部分沉淀 PVA 的水凝胶微/纳米纤维支架，和 (4) 基于交联 PVA 的水凝胶微/纳米纤维支架。这篇综述将指导研究人员选择适合自己目的的合适支架并开发更复杂的支架。