A new metabolite, cyclic dipeptide, cis-(3S,8aS)-3-(3,4-dihydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, named JS-3 was isolated from Streptomyces sp. 8812 fermentation broth. Its chemical structure was established by means of spectroscopic analysis. A wide-range-screening study, which included inhibition assay of DD-carboxypeptidase/transpeptidase activity, determination of antibacterial, antifungal, and antiproliferative activities as well as free-radical scavenging was performed. To authors knowledge, this is the first isolation of such compound from natural sources and the first one from bacteria, Streptomyces.

中文翻译：

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Cyclo（Pro-DOPA），是由链霉菌属产生的第三种鉴定出的生物活性代谢物。8812。

从链霉菌属的菌种中分离出一种新的代谢物，环状二肽，顺式-（3S，8aS）-3-（3,4-二羟基苄基）六氢吡咯并[1,2-a]吡嗪-1,4-二酮。8812发酵液。通过光谱分析确定其化学结构。进行了广泛的筛选研究，包括抑制DD-羧肽酶/转肽酶活性，测定抗菌，抗真菌和抗增殖活性以及清除自由基。据作者所知，这是首次从天然来源中分离出这种化合物，也是从细菌链霉菌中分离出了第一个化合物。