The effect of different polymeric coatings, including natural and synthetic compositions, on the mechanical performance of 45S5 bioglass robocast scaffolds is systematically analyzed in this work. Fully amorphous 45S5 bioglass robocast scaffolds sintered at 550 °C were impregnated with natural (gelatin, alginate, and chitosan) and synthetic (polycaprolactone, PCL and poly-lactic acid, PLA) polymers through a dip-coating process. Mechanical enhancement provided by these coatings in terms of both compressive strength and strain energy density was evaluated. Natural polymers, in general, and chitosan, in particular, were found to produce the greater reinforcement. The effect of these coatings on the in vitro bioactivity and degradation behavior of 45S5 bioglass robocast scaffolds was also investigated through immersion tests in simulated body fluid (SBF). Coatings from natural polymers, especially chitosan, are shown to have a positive effect on the bioactivity of 45S5 bioglass, accelerating the formation of an apatite-like layer. Besides, most coating compositions reduced the degradation (weight loss) rate of the scaffold, which has a positive impact on the evolution of their mechanical properties.

在这项工作中，系统地分析了不同的聚合物涂层（包括天然和合成成分）对45S5生物玻璃机器人铸造支架的机械性能的影响。通过浸涂工艺，将天然聚合物（明胶，藻酸盐和壳聚糖）和合成聚合物（聚己内酯，PCL和聚乳酸，PLA）浸渍在550°C烧结的完全无定形的45S5生物玻璃机器人铸造支架中。评价了这些涂层在抗压强度和应变能密度方面的机械增强作用。通常发现天然聚合物，尤其是壳聚糖产生更大的增强作用。这些涂料对体外的影响还通过在模拟体液（SBF）中的浸入测试研究了45S5生物玻璃机器人铸造支架的生物活性和降解行为。已显示，由天然聚合物（尤其是壳聚糖）制成的涂层对45S5生物玻璃的生物活性具有积极作用，可加速磷灰石样层的形成。此外，大多数涂料组合物减少了支架的降解（重量损失）速率，这对其支架的机械性能的发展具有积极影响。