The interaction of capecitabine (CAP) with cucurbit[7]uril (Q[7]) and inverted cucurbit[7]uril (iQ[7]) was investigated using nuclear magnetic resonance, fluorescence spectroscopy, MALDI-TOF mass spectrometry and isothermal titration calorimetry. The obtained results revealed that the alkyl chain of CAP is located inside the cavities of Q[7] or iQ[7], whereas the other section of CAP remains outside the portal. Our results suggest that both Q[7] and iQ[7] could be promising candidates for excipients used in medicinal and pharmaceutical research fields.

中文翻译：

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卡培他滨与葫芦[7]尿和倒葫芦[7]尿的超分子药物包合物

用核磁共振，荧光光谱，MALDI-TOF质谱和等温研究了卡培他滨（CAP）与葫芦[7]尿素（Q [7]）和倒葫芦[7]尿素（i Q [7]）的相互作用。滴定量热法。获得的结果表明，CAP的烷基链位于Q [7]或i Q [7]的腔内，而CAP的其他部分仍位于门的外部。我们的结果表明，Q [7]和i Q [7]都有望成为药用和药物研究领域中使用的赋形剂的候选者。