This work reports domino hydroformylation, hydrogenation and intramolecular keto-aldol condensation reactions for the selective synthesis of 1,5-dimethylhexahydro-1H-inden-4(2H)-one obtained from (R)-carvone and dihydrocarvone under homogeneous hydroformylation condition. The synthesis of the desired product was achieved by using conventional rhodium/1,3-bis(diphenylphosphino)propane (Rh/dppp) catalyst and PPTS (pyridinium p-toluenesulfonate) as an acidic co-catalyst. The reaction conditions were optimized with respect to various reaction parameters like time, temperature, synthesis gas (CO/H₂) pressure, solvents, catalyst and co-catalyst loading. The experimental results showed that less planner carbon backbone in dihydrocarvone increases the steric hindrance around the reaction site and responsible for the reactivity difference between (R)-carvone and dihydrocarvone.

这项工作报告多米诺加氢甲酰化，加氢和分子内的酮-醛醇缩合反应，用于在均相加氢甲酰化条件下选择性合成由（R）-香芹酮和二氢香芹酮制得的1,5-二甲基六氢-1H-inden-4（2H）- 。通过使用常规的铑/ 1,3-双（二苯基膦基）丙烷（Rh / dppp）催化剂和PPTS（对甲苯磺酸吡啶鎓）作为酸性助催化剂，可以实现所需产物的合成。针对各种反应参数（例如时间，温度，合成气（CO / H _2））对反应条件进行了优化）压力，溶剂，催化剂和助催化剂的负载量。实验结果表明，二氢香芹酮中较少的规划碳主链增加了反应位点附近的空间位阻，并造成了（R）-香芹酮与二氢香芹酮之间的反应性差异。