Background

Non-invasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new non-invasive fat removal treatments that are both safe and efficacious.

Objective

To assess the extent to which carboxytherapy, the insufflation of carbon dioxide gas into subcutaneous fat, results in reduction of fat volume.

Methods

Randomized, sham-controlled, split-body study. Adults (BMI 22-29) were randomized to receive five weekly infusions of 1000 cc CO₂ to one side of the abdomen, and five sham treatments to the contralateral side. Primary outcome measures were ultrasound measurement of fat layer thickness, as well as total circumference before and after treatment.

Results

Sixteen participants completed the study. Ultrasound measurement indicated less fat volume on the sides treated with carboxytherapy one week after the last treatment, (p=0.011), but was not maintained at 28 weeks. Total circumference decreased nominally but not significantly at Week 5 compared to baseline (p=0.0697). Participant body weights did not change over the entire course of the study (p=1.00)

Limitations

Limitations included modest sample size and some sources of error in circumference and fat layer measurements.

Conclusion

Carboxytherapy provides a transient decrease in subcutaneous fat that may not persist. Treatment is well-tolerated.

中文翻译：

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二氧化碳皮下渗透（羧化疗法）以减少腹部脂肪：一项随机临床试验

背景

由于减少停机时间和降低感知风险，因此首选非侵入式脂肪去除。寻求安全有效的新的非侵入性除脂治疗非常重要。

客观的

为了评估羧化疗法（将二氧化碳气体吹入皮下脂肪中）导致脂肪量减少的程度。

方法

随机，假对照，分裂体研究。成人（BMI 22-29）被随机分配到腹部一侧，每周接受五次1000 cc CO ₂输注，对侧一侧接受五次假治疗。主要的结局指标是超声测量脂肪层厚度以及治疗前后的总周长。

结果

十六名参与者完成了研究。超声测量表明，在最后一次治疗后1周，用羧基疗法治疗的一侧的脂肪量较少（p = 0.011），但在28周时并未维持。与基线相比，第5周总周长名义上下降，但没有明显下降（p = 0.0697）。在整个研究过程中，参与者体重均未发生变化（p = 1.00）

局限性

局限性包括适度的样本量以及周长和脂肪层测量中的一些误差源。

结论

羧基疗法可暂时减少皮下脂肪，这种脂肪可能不会持续存在。治疗耐受性良好。