Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color or texture on quality of life have not been described. This article reviews clinically significant therapy-related hair disorders in cancer patients, underlying pathophysiological mechanisms, severity grading scales, patient reported quality of life instruments, management strategies, and future translational research opportunities.

细胞毒性化学疗法，分子靶向疗法，免疫疗法，放射疗法，干细胞移植和内分泌疗法可能会导致头发疾病（包括脱发，多毛症，多毛症，色素和发质的改变）。这些变化的潜在机制是多种多样的，并且仍未完全理解，从而阻碍了预防或治疗指南的发展。化疗引起的脱发的社会心理影响主要在肿瘤学文献中得到了充分的文献证明，但是还没有描述其他改变，例如辐射引起的脱发，多毛症，头发颜色或质地的改变对生活质量的影响。本文回顾了与癌症患者有关的与临床治疗相关的重大临床疾病，潜在的病理生理机制，严重程度分级，