Platelet-derived growth factor (PDGF-BB), a significant serum cytokine, is an important protein biomarker in diagnosis and recognition of cancer, which straightly rolled in proceeding of various cell transformations, including tumor growth and its development. Fibrosis, atherosclerosis are certain appalling diseases, which PDGF-BB is near to them. Generally, the expression amount of PDGF-BB increases in human life-threatening tumors serving as an indicator for tumor angiogenesis. Thus, identification and quantification of PDGF-BB in biomedical fields are particularly important. Affinity chromatography, immunohistochemical methods and enzyme-linked immunosorbent assay (ELISA), conventional methods for PDGF-BB detection, requiring high-cost and complicated instrumentation, take too much time and offer deficient sensitivity and selectivity, which restrict their usage in real applications. Hence, it is essential to design and build enhanced systems and platforms for the recognition and quantification of protein biomarkers. In the past few years, biosensors especially aptasensors have been received noticeable attention for the detection of PDGF-BB owing to their high sensitivity, selectivity, accuracy, fast response, and low cost. Since the role and importance of developing aptasensors in cancer diagnosis is undeniable. In this review, optical and electrochemical aptasensors, which have been applied by many researchers for PDGF-BB cancer biomarker detection, have been mentioned and merits and demerits of them have been explained and compared. Efforts related to design and development of aptamer-based biosensors using nanoparticles for sensitive and selective detection of PDGF-BB have been reviewed considering: Aptamer importance as recognition elements, principal, application and the recent improvements and developments of aptamer based optical and electrochemical methods. In addition, commercial biosensors and future perspectives for rapid and on-site detection of PDGF-BB have been summarized.

血小板衍生生长因子（PDGF-BB）是一种重要的血清细胞因子，是诊断和识别癌症的重要蛋白质生物标志物，直接在包括肿瘤生长及其发展在内的各种细胞转化过程中不断发展。纤维化，动脉粥样硬化是某些令人震惊的疾病，PDGF-BB靠近它们。通常，PDGF-BB的表达量在威胁人类生命的肿瘤中增加，其充当肿瘤血管生成的指标。因此，在生物医学领域中PDGF-BB的鉴定和定量尤为重要。亲和色谱法，免疫组化方法和酶联免疫吸附测定（ELISA）是PDGF-BB检测的常规方法，需要昂贵且昂贵的仪器，需花费大量时间，且灵敏度和选择性不足，这限制了它们在实际应用中的使用。因此，设计和构建用于识别和定量蛋白质生物标志物的增强系统和平台至关重要。在过去的几年中，由于生物传感器特别是适体传感器的高灵敏度，选择性，准确性，快速响应和低成本，其在PDGF-BB的检测中受到了广泛的关注。由于开发适体传感器在癌症诊断中的作用和重要性是不可否认的。在这篇综述中，已经提到了许多研究人员已将其用于PDGF-BB癌症生物标志物检测的光学和电化学适体传感器，并对它们的优缺点进行了解释和比较。考虑到：适体作为识别元件的重要性，原理，应用以及基于适体的光学和电化学方法的最新改进和发展，已经综述了与使用纳米颗粒对PDGF-BB进行灵敏和选择性检测的基于适体的生物传感器的设计和开发有关的努力。另外，已经总结了商业生物传感器以及用于PDGF-BB的快速和现场检测的未来前景。