Long noncoding RNAs (lncRNAs) are a class of noncoding RNA, involved in regulation of diverse physiological and pathological processes. Ovarian cancer is the leading cause of death among all gynecological malignancies in the world and its underlying mechanism is still unclear. LncRNAs exhibit multiple biological functions in various stages of ovarian cancer development. We will discuss and summarize the new and important lncRNAs and their involvement in disease, which might represent promising therapeutic targets. Therapeutic intervention based on silencing or functional inhibition of target lncRNAs will be beneficial for ovarian cancer patients.

中文翻译：

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lncRNA在卵巢癌中的作用：为治疗目的定义新的生物标记

长非编码RNA（lncRNA）是一类非编码RNA，涉及多种生理和病理过程的调控。卵巢癌是世界上所有妇科恶性肿瘤中主要的死亡原因，其潜在机制仍不清楚。LncRNA在卵巢癌发展的各个阶段均表现出多种生物学功能。我们将讨论和总结新的和重要的lncRNA及其在疾病中的参与，这可能代表有希望的治疗靶标。基于沉默或对目标lncRNAs的功能抑制的治疗干预将对卵巢癌患者有益。