Eleven previously undescribed lanostane-type triterpene glycosides, hebecarposides A−K, were isolated from the leaves of Lyonia ovalifolia var. hebecarpa (Ericaceae), along with two known analogues, lyonifolosides L and O. The structures of hebecarposides A−K were established by extensive spectroscopic analysis and chemical methods, and the absolute configuration of C-24 in hebecarposides A and E was determined to be S and R, respectively, by a Mo₂(OAc)₄−induced electronic circular dichroism method. This is the first report of the presence of lanostane-type triterpene glycosides in L. ovalifolia var. hebecarpa. All compounds were evaluated for their antiproliferative activities against five cancer cell lines, SMMC-7721, HL-60, SW480, MCF-7, and A-549, and a normal epithelial cell line BEAS-2B, and none of them showed general cytotoxity to the normal cell line BEAS-2B. Interestingly, hebecarposides C, D, G, and K selectively inhibited the proliferation of HL-60 and SMMC-7721 cell lines, and hebecarposides C and D showed significant anti-proliferative activities against A-549 cell lines than the positive control, cis-platin. In addition, hebecarposides C and H exhibited more potent anti-proliferative activities against MCF-7 than cis-platin.

从卵白Lyonia叶中分离出11种先前未描述的羊毛甾烷型三萜糖苷hebecarposides A-K 。hebecarpa（Ericaceae）以及两个已知的类似物，lyonifolosides L和O。通过广泛的光谱分析和化学方法建立了hebecarposides A-K的结构，并确定了hebecarposides A和E中C-24的绝对构型为S和R分别通过Mo ₂（OAc）_4-诱导的电子圆二色性方法。这是关于卵圆叶紫苏中羊毛甾烷型三萜糖苷的首次报道。赫贝卡帕。评估了所有化合物对五种癌细胞系SMMC-7721，HL-60，SW480，MCF-7和A-549以及正常上皮细胞系BEAS-2B的抗增殖活性，但它们均未显示出一般的细胞毒性到正常细胞系BEAS-2B。有趣的是，hebecarposides C，D，G和K选择性抑制HL-60和SMMC-7721细胞系的增殖，并且hebecarposides C和D对A-549细胞系的抑制增殖活性均高于阳性对照cis-。铂金。另外，hebecarposides C和H表现出比顺铂更有效的抗MCF-7的抗增殖活性。