The use of biobased plastics is of great importance for many applications. Blending thermoplastic polylactide (PLA) with polyhydroxyalkanoate (PHA) enables the formulation of a more mechanically powerful material and this enables tailored biodegradation properties. In this study we demonstrate the 3D printing of a PLA/PHA blend as a potential candidate for biocompatible material applications. The filament for 3D printing consisted of PHA, which contains predominantly 3-hydroxybutyrate units and a small amount of 3-hydroxyvalerate units, as revealed by multistage mass spectrometry (ESI-MSⁿ). This research found that the properties of 3D printed species before and during abiotic degradation are dependent on printing orientation. Furthermore, the 3D printed specimens exhibited good biocompatibility with HEK293 cells, indicating real promise as biological scaffolds for tissue engineering applications.

对于许多应用而言，生物基塑料的使用非常重要。将热塑性聚丙交酯（PLA）与聚羟基链烷酸酯（PHA）混合，可以配制出机械强度更高的材料，从而可以实现定制的生物降解性能。在这项研究中，我们演示了PLA / PHA共混物的3D打印作为生物相容性材料应用的潜在候选者。多级质谱分析（ESI-MS ^n）显示，用于3D打印的灯丝由PHA组成，该PHA主要包含3-羟基丁酸酯单元和少量3-羟基戊酸酯单元。）。这项研究发现，非生物降解之前和之中的3D打印物种的属性取决于打印方向。此外，3D打印的标本与HEK293细胞表现出良好的生物相容性，表明作为组织工程应用的生物支架的真正前景。