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An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women
Methods ( IF 4.8 ) Pub Date : 2018-04-24
Bin Wu, Jingshan Huang, Lihua Zhang, Mohan Vamsi Kasukurthi, Fangwan Huang, Jiang Bian, Keisuke Fukuo, Tsutomu Kazumi

Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women. Research outcomes in this study resulted in two novel discoveries. Discovery 1: There are four primary determinants for hs-CRP, i.e., central/abdominal FM (a.k.a. trunk FM) accumulation, leptin, high density lipoprotein cholesterol (HDL-C), and plasminogen activator inhibitior-1 (PAI-1). Discovery 2: Chronic inflammation may involve in adipocyte-cytokine interaction underlying the metabolic derangement in healthy young women.



中文翻译:

研究年轻健康女性中高敏C反应蛋白,体脂质量分布和其他心脏代谢危险因素之间关联的综合方法

先前的研究表明,作为慢性低度炎症的重要生物标志物,高敏感性C反应蛋白(hs-CRP)可以在代谢综合征和心血管疾病(CVD)的发作中发挥重要作用。我们进行了一个综合方法,该方法结合了生物湿实验室实验,统计分析以及面向语义的生物信息学和计算分析,以研究hs-CRP,体脂量(FM)分布和其他年轻人代谢危险因素之间的关联健康的女性。这项研究的研究成果导致了两个新颖的发现。发现1:hs-CRP有四个主要决定因素,即中央/腹部FM(又称躯干FM)积累,瘦素,高密度脂蛋白胆固醇(HDL-C)和纤溶酶原激活物抑制因子1(PAI-1)。发现2:

更新日期:2018-04-25
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