Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.

中文翻译：

---

Hamuramicins A和B，由内生放线菌Allostreptomyces sp。生产的22元大环内酯类。K12-0794。

从内生放线菌Allostreptomyces sp。的培养液中分离出两种新化合物，分别称为hamuramicins A（1）和B（2）。通过硅胶柱色谱法和HPLC测定K12-0794。通过包括NMR实验在内的光谱分析，阐明了1和2的结构为22元大环内酯，其含有带有烷基侧链的三烯和三烯酮。两种化合物均显示出对根腐菌和米黄单胞菌PV的生长抑制活性。稻米以及人类细胞系的毒性。