An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N‐Methyltransferase Gene Expression,Molecular Nutrition & Food Research

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An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N‐Methyltransferase Gene Expression
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-06-19 , DOI: 10.1002/mnfr.201700933
Ana B Crujeiras ₁ , Pavlos Pissios ₂ , Jose M Moreno-Navarrete ₃ , Angel Diaz-Lagares ₄ , Juan Sandoval ₅ , Antonio Gomez ₆ , Wilfredo Ricart ₃ , Manel Esteller ₇ , Felipe F Casanueva ₁ , Jose M Fernandez-Real ₃

Affiliation

Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS) and Santiago de Compostela University (USC), Santiago de Compostela 15706, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, 28029, Spain.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona, Girona, 77190 Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, 28029, Spain.
Translational Medical Oncology (Oncomet), Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS) and CIBERonc, Santiago de Compostela, 15706, Spain.
Laboratory of Personalized Medicine, Epigenomics Unit, Medical Research Institute La Fe, Valencia, 46026, Spain.
Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, 08908, Spain.
Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia 08908, Spain, Institucio Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys, 23, Barcelona, 08010, Spain.

The enzyme nicotinamide N‐methyltransferase (NNMT) is a major methyltransferase in adipose tissue. We hypothesized an epigenetic signature in association with NNMT gene expression in adipose tissue.

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