Metabolomics‐Based Dietary Biomarkers in Nutritional Epidemiology—Current Status and Future Opportunities,Molecular Nutrition & Food Research

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Metabolomics‐Based Dietary Biomarkers in Nutritional Epidemiology—Current Status and Future Opportunities
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-05-28 , DOI: 10.1002/mnfr.201701064
Lorraine Brennan ₁ , Frank B Hu _{2,

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Affiliation

The application of metabolomics in nutrition epidemiology holds great promise and there is a high expectation that it will play a leading role in deciphering the interactions between diet and health. However, while significant progress has been made in the identification of putative biomarkers, more work is needed to address the use of the biomarkers in dietary assessment. The aim of this review is to critically evaluate progress in these areas and to identify challenges that need to be addressed going forward. The notable applications of dietary biomarkers in nutritional epidemiology include 1) determination of food intake based on biomarkers levels and calibration equations from feeding studies, 2) classification of individuals into dietary patterns based on the urinary metabolic profile, and 3) application of metabolome wide–association studies. Further work is needed to address some specific challenges to enable biomarkers to reach their full potential.

中文翻译：

营养流行病学中基于代谢组学的膳食生物标志物——现状和未来机遇

代谢组学在营养流行病学中的应用前景广阔，人们寄予厚望，它将在破译饮食与健康之间的相互作用方面发挥主导作用。然而，虽然在确定假定的生物标志物方面取得了重大进展，但还需要做更多的工作来解决生物标志物在膳食评估中的使用问题。本次审查的目的是批判性地评估这些领域的进展，并确定未来需要解决的挑战。饮食生物标志物在营养流行病学中的显着应用包括 1）根据生物标志物水平和喂养研究的校准方程确定食物摄入量，2）根据尿液代谢特征将个体分类为饮食模式，以及 3）代谢组广泛应用 –协会研究。

更新日期：2018-05-28

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