Highly Efficient Construction of 2‐Fluoroalkyl Quinolines through a Palladium‐Catalyzed 6‐endo‐trig Heck Cyclization Reaction,Asian Journal of Organic Chemistry

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Highly Efficient Construction of 2‐Fluoroalkyl Quinolines through a Palladium‐Catalyzed 6‐endo‐trig Heck Cyclization Reaction
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-05-23 , DOI: 10.1002/ajoc.201800187
Fangwai Han ₁ , Wenqing Yang ₁ , Aichun Zhao ₁ , Ruihong Zheng ₁ , Chenhui Ji ₁ , Xinqi Liu ₁ , Guiyan Liu ₁ , Chen Chen ₁

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A highly efficient Pd⁰‐catalyzed 6‐endo‐trig Heck cyclization reaction has been developed for the construction of 2‐fluoroalkyl quinolines, which are important structural motifs for bioactive molecules. This process offers broad substrate scope, with excellent 6‐endo selectivity, and affords quinoline derivatives in moderate‐to‐excellent yields.

中文翻译：

通过钯催化的6-endo-trig Heck环化反应高效构建2-氟烷基喹啉

A高效的Pd ⁰ -催化的6-内切-trig的Heck环化反应已为2-喹啉氟烷基，其是对生物活性分子的重要结构基序的结构发展。该方法可提供广泛的底物范围，并具有出色的6内酯选择性，并能以中等至优异的产率提供喹啉衍生物。

更新日期：2018-05-23

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