Understanding the tumor immune microenvironment (TIME) for effective therapy.,Nature Medicine

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Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nature Medicine ( IF 58.7 ) Pub Date : 2018-04-23 , DOI: 10.1038/s41591-018-0014-x
Mikhail Binnewies ₁ , Edward W Roberts ₁ , Kelly Kersten ₁ , Vincent Chan ₂ , Douglas F Fearon ₃ , Miriam Merad ₄ , Lisa M Coussens ₅ , Dmitry I Gabrilovich ₆ , Suzanne Ostrand-Rosenberg _{7,

8} , Catherine C Hedrick ₉ , Robert H Vonderheide ₁₀ , Mikael J Pittet ₁₁ , Rakesh K Jain ₁₂ , Weiping Zou ₁₃ , T Kevin Howcroft ₁₄ , Elisa C Woodhouse ₁₄ , Robert A Weinberg ₁₅ , Matthew F Krummel _{1,

2}

Affiliation

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.
The Wistar Institute, Philadelphia, PA, USA.
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA.
Huntsman Cancer Institute and Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Division of Cancer Biology, NCI, NIH, Bethesda, MD, USA.
Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient's tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.

中文翻译：

了解肿瘤免疫微环境（TIME）以进行有效治疗。

免疫疗法的临床成功令人震惊，但同时又不尽人意。无数具有不同肿瘤类型的患者在免疫治疗干预下已表现出明显的临床反应。然而，更多的患者在接受同样的治疗后却没有或只有很少的临床获益。随着技术的进步，人们对肿瘤微环境免疫环境的复杂性和多样性及其对治疗反应的影响的理解也日益加深。有可能鉴定出不同的免疫环境亚类，这些亚类会影响肿瘤的发生，反应和治疗。通过解析患者肿瘤内存在的独特的肿瘤免疫微环境（TIME）类和子类，

更新日期：2018-04-23

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