Kinetic Resolution of α‐Hydroxy‐Substituted Oxime Ethers by Enantioselective Cu−H‐Catalyzed Si−O Coupling,Angewandte Chemie International Edition

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Kinetic Resolution of α‐Hydroxy‐Substituted Oxime Ethers by Enantioselective Cu−H‐Catalyzed Si−O Coupling
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-04-23 , DOI: 10.1002/anie.201802947
Xichang Dong ₁ , Yuji Kita ₁ , Martin Oestreich ₁

Affiliation

A catalyst‐controlled enantioselective alcohol silylation by Cu−H‐catalyzed dehydrogenative Si−O coupling of hydroxy groups α to an oxime ether and simple hydrosilanes is reported. The selectivity factors reached in this kinetic resolution are generally high (s≈50), and these reactions thereby provide reliable access to highly enantioenriched α‐hydroxy‐substituted oxime ethers. The synthetic usefulness of these compounds is also demonstrated.

中文翻译：

对映选择性Cu-H-催化的Si-O偶联的α-羟基取代的肟醚的动力学拆分

据报道，通过Cu-H催化的α-羟基与肟醚和简单的氢硅烷的脱氢Si-O偶联，可以控制催化剂控制的对映选择性醇的甲硅烷基化反应。在此动力学拆分达到选择性的因素通常是高（š ≈50），和这些反应从而提供对映体富集的高度α羟基-取代的肟醚的可靠访问。还证明了这些化合物的合成有用性。

更新日期：2018-04-23

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