Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research
Chemical Reviews ( IF 62.1 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1021/acs.chemrev.7b00661
David Perez-Guaita ₁ , Katarzyna M. Marzec _{2,

3} , Andrew Hudson ₄ , Corey Evans ₄ , Tatyana Chernenko ₅ , Christian Matthäus _{6,

7} , Milos Miljkovic ₈ , Max Diem ₉ , Philip Heraud ₁ , Jack S. Richards _{10,

11,

12} , Dean Andrew ₁₀ , David A. Anderson ₁₀ , Christian Doerig ₁₃ , Jose Garcia-Bustos ₁₃ , Don McNaughton ₁ , Bayden R. Wood ₁

Affiliation

Centre for Biospectroscopy, School of Chemistry, Monash University, Clayton, Victoria 3800, Australia
Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzyńskiego 14, Kraków 30-348, Poland
Center for Medical Genomics (OMICRON), Jagiellonian University, Kopernika 7C, Krakow 31-034, Poland
Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
Becton Dickinson and Company, 2350 Qume Drive, San Jose, California 95131, United States
Leibniz Institute of Photonic Technology, Albert Einstein Straße 9, Jena 07745, Germany
Institute of Physical Chemistry and Abbe School of Photonics, Friedrich Schiller University, Helmholtz Weg 4, Jena 07743, Germany
Department of Mechanical Engineering, Tufts University, 200 Boston Avenue, Medford, Massachusetts 02155, United States
Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, 316 Hurtig Hall, 360 Huntington Avenue, Boston, Massachusetts 02155, United States
Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria 3004, Australia
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
Department of Medicine, University of Melbourne, Parkville, Victoria 3050, Australia
Department of Microbiology and the Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia

New technologies to diagnose malaria at high sensitivity and specificity are urgently needed in the developing world where the disease continues to pose a huge burden on society. Infrared and Raman spectroscopy-based diagnostic methods have a number of advantages compared with other diagnostic tests currently on the market. These include high sensitivity and specificity for detecting low levels of parasitemia along with ease of use and portability. Here, we review the application of vibrational spectroscopic techniques for monitoring and detecting malaria infection. We discuss the role of vibrational (infrared and Raman) spectroscopy in understanding the processes of parasite biology and its application to the study of interactions with antimalarial drugs. The distinct molecular phenotype that characterizes malaria infection and the high sensitivity enabling detection of low parasite densities provides a genuine opportunity for vibrational spectroscopy to become a front-line tool in the elimination of this deadly disease and provide molecular insights into the chemistry of this unique organism.

更新日期：2018-04-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>