A Dynamic Chemical Network for Cystinuria Diagnosis,Angewandte Chemie International Edition

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A Dynamic Chemical Network for Cystinuria Diagnosis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-04-20 , DOI: 10.1002/anie.201802189
Maria Lafuente ₁ , Jordi Solà ₁ , Ignacio Alfonso ₁

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The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non‐covalent interactions, the design of stimulus‐responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. The binding and sensing units are encoded in the components that dynamically assemble and disassemble responding to external stimuli as a successful tool to detect both cysteine and cystine in aqueous media. Moreover, the dynamic sensing system works in human urine, as a prospective application for cystinuria diagnosis.

中文翻译：

动态化学网络用于诊断尿毒症

分子网络的研究代表了化学领域的概念革命。在先前知识的基础上，并在理解了非共价相互作用的规则之后，就可以设计出刺激反应型化学系统。本文中，我们报告了一种基于动态化学网络重组的新策略，该动态化学网络在半胱氨酸或胱氨酸的存在下会产生新的荧光缔合。结合和传感单元编码在响应外部刺激而动态组装和拆卸的组件中，是检测水性介质中半胱氨酸和半胱氨酸的成功工具。此外，动态传感系统可在人尿中发挥作用，作为胱氨酸尿症诊断的前瞻性应用。

更新日期：2018-04-20

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