A new polyenyl-α-pyrone polyketide, aspopyrone A (1), was isolated from a culture broth of Okinawan plant-associated Aspergillus sp. TMPU1623 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was assigned based on NMR experiments. Compound 1 exhibited protein tyrosine phosphatase (PTP) 1B and T-cell PTP (TCPTP) inhibitory activities with IC₅₀ values of 6.7 and 6.0 μM, respectively.

中文翻译：

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冲绳植物相关曲霉的一种新蛋白酪氨酸磷酸酶1B抑制性α-吡喃酮型聚酮化合物。TMPU1623。

从冲绳植物相关的曲霉菌的培养液中分离出一种新的多烯基-α-吡喃酮聚酮化合物，即pop酮A（1）。通过溶剂萃取，ODS柱色谱和制备型HPLC（ODS）提取TMPU1623。1的结构根据NMR实验确定。化合物1表现出蛋白质酪氨酸磷酸酶（PTP）1B和T细胞PTP（TCPTP）抑制活性，IC ₅₀值分别为6.7和6.0μM 。