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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates†‡
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1039/c8md00141c
Oleksandr Koniev 1, 2, 3 , Igor Dovgan 3, 4, 5, 6, 7 , Brigitte Renoux 3, 8, 9, 10, 11 , Anthony Ehkirch 3, 12, 13, 14, 15 , Jitka Eberova 3, 4, 5, 6, 7 , Sarah Cianférani 3, 12, 13, 14, 15 , Sergii Kolodych 1, 2, 3 , Sébastien Papot 3, 8, 9, 10, 11 , Alain Wagner 3, 4, 5, 6, 7
Affiliation  

The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

中文翻译:

制备基于ADPN的抗体-药物偶联物的还原-再混合策略

减少-再杂交策略是制备稳定且均质的抗体-药物偶联物(ADC)的有力方法。在本交流中,我们描述了用于还原二硫键还原的亚芳基二丙腈(ADPN)官能团的开发及其在制备有效和选择性ADC中的应用。
更新日期:2018-04-20
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