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Natural deep eutectic solvents as new green solvents to extract anthraquinones from Rheum palmatum L.
RSC Advances ( IF 3.9 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1039/c7ra13581e Y C Wu 1 , P Wu 1 , Y B Li 1, 2 , T C Liu 1 , L Zhang 1 , Y H Zhou 3
RSC Advances ( IF 3.9 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1039/c7ra13581e Y C Wu 1 , P Wu 1 , Y B Li 1, 2 , T C Liu 1 , L Zhang 1 , Y H Zhou 3
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Natural deep eutectic solvents (NADESs) are efficient in extracting natural products. However, traditional organic solvents are toxic in the extraction of anthraquinones from Rheum palmatum L. To solve this problem, we applied natural deep eutectic solvent ultrasound-assisted extraction in this study for the extraction of total anthraquinones from R. palmatum L. Principal component analysis revealed that the selected NADES which consisted of lactic acid, glucose and water (LGH), was highly efficient in extracting anthraquinones from R. palmatum L. The ratio of lactic acid/glucose and the addition of water in LGH were investigated via a single-factor experiment. With a lactic acid/glucose ratio of 5 : 1 (mol/mol), and 10% of water (v/v), LGH had a high extraction yield to anthraquinones. Optimized by response surface methodology (RSM), the optimized extraction conditions of extraction time, extraction temperature and solvent-to-solid ratio of 1.5 h, 82 °C and 26 mL g−1, respectively. Under optimum conditions, the extraction yields of aloe-emodin, rhein, emodin, chrysophanol, physcion and total anthraquinones were 2.60 ± 0.01, 5.78 ± 0.02, 2.21 ± 0.02, 5.87 ± 0.02, 8.81 ± 0.01 and 25.27 ± 0.07 mg g−1, respectively. The enrichment and separation of five anthraquinones in LGH extraction solution were efficiently achieved using DM130 macroporous resin, with purities of 90.98%, 96.67%, 92.37%, 95.80% and 91.61% as indicated by HPLC, and recovery yields of 84.08%, 79.51%, 84.96%, 81.83% and 78.35%, respectively. LGH was environmentally friendly and highly efficient in extracting anthraquinones from R. palmatum L., and NADESs showed potential for the extraction of effective components from natural products.
中文翻译：
天然低共熔溶剂作为新的绿色溶剂提取大黄中的蒽醌。
天然低共熔溶剂 (NADES) 可有效提取天然产物。然而，传统的有机溶剂在提取大黄中的蒽醌时存在毒性。为解决这一问题，本研究采用天然低共熔溶剂超声辅助提取法提取大黄中的总蒽醌。主成分分析揭示了选择的由乳酸、葡萄糖和水 (LGH) 组成的 NADES 能够高效地从 R. palmatum L 中提取蒽醌。单因素实验。在乳酸/葡萄糖比为 5 : 1 (mol/mol) 和 10% 的水 (v/v) 下，LGH 对蒽醌的提取率很高。通过响应面法（RSM）优化，提取时间、提取温度和溶剂固比的优化提取条件分别为1.5 h、82 ℃和26 mL g -1。在最佳条件下，芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素和总蒽醌的提取得率分别为2.60±0.01、5.78±0.02、2.21±0.02、5.87±0.02、8.81±0.01和25.27±0.07 mg g -1， 分别。DM130大孔树脂高效富集和分离LGH提取液中的五种蒽醌类化合物，HPLC表明纯度分别为90.98%、96.67%、92.37%、95.80%和91.61%，回收率分别为84.08%、79.51% ，分别为 84.96%、81.83% 和 78.35%。LGH在从R. palmatum L.中提取蒽醌方面对环境友好且高效，NADESs显示出从天然产物中提取有效成分的潜力。
更新日期：2018-04-20
中文翻译：
天然低共熔溶剂作为新的绿色溶剂提取大黄中的蒽醌。
天然低共熔溶剂 (NADES) 可有效提取天然产物。然而，传统的有机溶剂在提取大黄中的蒽醌时存在毒性。为解决这一问题，本研究采用天然低共熔溶剂超声辅助提取法提取大黄中的总蒽醌。主成分分析揭示了选择的由乳酸、葡萄糖和水 (LGH) 组成的 NADES 能够高效地从 R. palmatum L 中提取蒽醌。单因素实验。在乳酸/葡萄糖比为 5 : 1 (mol/mol) 和 10% 的水 (v/v) 下，LGH 对蒽醌的提取率很高。通过响应面法（RSM）优化，提取时间、提取温度和溶剂固比的优化提取条件分别为1.5 h、82 ℃和26 mL g -1。在最佳条件下，芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素和总蒽醌的提取得率分别为2.60±0.01、5.78±0.02、2.21±0.02、5.87±0.02、8.81±0.01和25.27±0.07 mg g -1， 分别。DM130大孔树脂高效富集和分离LGH提取液中的五种蒽醌类化合物，HPLC表明纯度分别为90.98%、96.67%、92.37%、95.80%和91.61%，回收率分别为84.08%、79.51% ，分别为 84.96%、81.83% 和 78.35%。LGH在从R. palmatum L.中提取蒽醌方面对环境友好且高效，NADESs显示出从天然产物中提取有效成分的潜力。
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