In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy†,Chemical Communications

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In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1039/c8cc01336e
Zhu Mao _{1,

2,

3,

4,

5} , Zhuo Liu _{3,

4,

6} , Jin Yang _{2,

3,

4,

7,

8} , Xiaoxia Han _{1,

2,

3,

4} , Bing Zhao _{1,

2,

3,

4} , Chun Zhao _{2,

3,

4,

9,

10}

Affiliation

Currently, studies are increasingly focusing on the cytotoxic effects of anticancer drugs. Such investigations urgently warrant the assessment of single-cell viability. Here, we developed a novel method for quantifying single-cell viability with high selectivity by resonance Raman scattering. We report on this powerful tool that will allow researchers to study cellular metabolism at the level of a single cell.

中文翻译：

通过共振拉曼光谱原位半定量评估单细胞活力†

当前，研究越来越集中在抗癌药的细胞毒性作用上。此类调查迫切需要对单细胞生存力进行评估。在这里，我们开发了一种通过共振拉曼散射定量分析具有高选择性的单细胞活力的新方法。我们报告了这一功能强大的工具，该工具将使研究人员能够在单个细胞水平上研究细胞代谢。

更新日期：2018-04-20

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