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Remote‐Loaded Platelet Vesicles for Disease‐Targeted Delivery of Therapeutics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-04-19 , DOI: 10.1002/adfm.201801032
Man Ying 1 , Jia Zhuang 1 , Xiaoli Wei 1 , Xinxin Zhang 1 , Yue Zhang 1 , Yao Jiang 1 , Diana Dehaini 1 , Mengchun Chen 1 , Silun Gu 1 , Weiwei Gao 1 , Weiyue Lu 2 , Ronnie H Fang 1 , Liangfang Zhang 1
Affiliation  

The recent emergence of biomimetic nanotechnology has facilitated the development of next‐generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, this study reports on the remote loading of small molecule therapeutics into cholesterol‐enriched platelet membrane‐derived vesicles for disease‐targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved. Leveraging the surface markers found on platelet membranes, the resultant nanoformulations demonstrate natural affinity toward both breast cancer cells and methicillin‐resistant Staphylococcus aureus. In vivo, this translates to improved disease targeting, increasing the potency of the encapsulated drug payloads compared with free drugs and the corresponding nontargeted nanoformulations. Overall, this work demonstrates that the remote loading of drugs into functional platelet membrane‐derived vesicles is a facile means of fabricating targeted nanoformulations, an approach that can be easily generalized to other cell types in the future.

中文翻译:

用于疾病靶向治疗药物递送的远程加载血小板囊泡

最近出现的仿生纳米技术促进了能够增强生物界面的下一代纳米递送系统的开发。特别是,直接使用天然细胞膜可以实现多价靶向功能。在此,本研究报告了将小分子治疗剂远程装载到富含胆固醇的血小板膜衍生囊泡中,以进行疾病靶向递送。使用这种方法,可以实现两种模型药物阿霉素和万古霉素的高装载量。利用血小板膜上发现的表面标记,所得纳米制剂表现出对乳腺癌细胞和耐甲氧西林金黄色葡萄球菌的天然亲和力。在体内,这转化为改善的疾病靶向性,与游离药物和相应的非靶向纳米制剂相比,增加了封装药物有效负载的效力。总的来说,这项工作表明,将药物远程装载到功能性血小板膜衍生囊泡中是制造靶向纳米制剂的一种简便方法,这种方法将来可以很容易地推广到其他细胞类型。
更新日期:2018-04-19
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