Synthesis ( IF 2.2 ) Pub Date : 2018-04-19 , DOI: 10.1055/s-0036-1591568 Tharmalingam Punniyamurthy 1 , Pinaki De 1 , Sourav Pradhan 1 , Tariq Shah 1
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Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis
Abstract
Iodine-mediated cyclization of benzimidazolylethylamines in the presence of base to give dihydroimidazobenzimidazoles via a dehydrogenative cross-coupling of C(sp2)–H and N–H bonds is reported. Metal-free conditions, preservation of the optical purity, and substrate scope are the important practical features.
Iodine-mediated cyclization of benzimidazolylethylamines in the presence of base to give dihydroimidazobenzimidazoles via a dehydrogenative cross-coupling of C(sp2)–H and N–H bonds is reported. Metal-free conditions, preservation of the optical purity, and substrate scope are the important practical features.
中文翻译：
碘介导的苯并咪唑分子内C–H胺化：无金属合成二氢咪唑并苯并咪唑的途径
作为专题“现代耦合方法及其在综合中的战略应用”的一部分发布
抽象的
据报道，在碱的存在下，碘介导的苯并咪唑基乙胺的环化反应会通过C（sp 2）–H和N–H键的脱氢交叉偶联反应生成二氢咪唑并苯并咪唑。无金属条件，保持光学纯度和基材范围是重要的实用功能。
据报道，在碱的存在下，碘介导的苯并咪唑基乙胺的环化反应会通过C（sp 2）–H和N–H键的脱氢交叉偶联反应生成二氢咪唑并苯并咪唑。无金属条件，保持光学纯度和基材范围是重要的实用功能。
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