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A unifying concept in vascular health and disease
Science ( IF 56.9 ) Pub Date : 2018-04-19 , DOI: 10.1126/science.aat3470
Martin A. Schwartz 1, 2, 3 , Dietmar Vestweber 4 , Michael Simons 1, 2
Affiliation  

Interventions to restore blood vessel stability could improve health outcomes Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. But is this really the case? An evaluation of the literature suggests that unresolved vascular remodeling may be a key element of virtually all vascular diseases. This commonality raises the possibility of unifying principles that govern vascular remodeling and the possibility that methods to restore normal remodeling could effectively treat multiple disease states.

中文翻译:

血管健康和疾病的统一概念

恢复血管稳定性的干预措施可以改善健康结果与托尔斯泰关于幸福家庭与不幸家庭的评论不同,血管生物学的当前智慧认为健康的血管大多相似,而不同血管疾病的血管则大多不同。但事实真的如此吗?对文献的评估表明,未解决的血管重塑可能是几乎所有血管疾病的关键因素。这种共性提出了统一管理血管重塑原则的可能性,以及恢复正常重塑的方法可以有效治疗多种疾病状态的可能性。
更新日期:2018-04-19
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