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DARK Side of Amphetamine and Analogues: Pharmacology, Syndromic Manifestation, and Management of Amphetamine Addiction
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1021/acschemneuro.8b00137
Abdul Mannan Baig 1
Affiliation  

The threat imposed by the use of psychoactive, illicit drugs on human health and the cost of rehabilitation of the affected individuals is nothing less than billions of dollars per year. Of the psychoactive substance abuse drugs are amphetamine and its analogues like methamphetamine. This Viewpoint intends to draw the attention of readers toward the neurological basis of “falling a prey” to methamphetamine. Attention has been paid toward a rapid desensitizing attribute that develops shortly after the repetitive use of drugs belonging to sympathomimetic agents of this group. Also summarized are the changes in physical characteristics and behavioral changes that could herald the loved ones around the methamphetamine abuser to seek the help of healthcare professionals before permanent and irreversible neurological damage ensues. A brief pharmacology of methamphetamine also precedes the management of these patients, for which no standard procedures exist at present.

中文翻译:

苯丙胺及其类似物的暗面:药理学,症状表现和苯丙胺成瘾的管理

使用精神药物和非法药物对人类健康的威胁以及受影响个人的康复费用每年不少于数十亿美元。滥用精神活性药物的药物包括苯丙胺及其类似物,如甲基苯丙胺。该观点旨在将读者的注意力吸引到“沦为甲基苯丙胺的猎物”的神经学基础上。在重复使用属于该组拟交感神经药的药物后不久出现的快速脱敏特性引起了人们的注意。还总结了身体特征和行为的变化,这些变化可能预示着甲基苯丙胺滥用者周围的亲人在永久性和不可逆转的神经损伤发生之前寻求医疗保健专业人员的帮助。
更新日期:2018-04-19
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