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Asymmetric Organocatalysis in Drug Development—Highlights of Recent Patent Literature
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1021/acs.oprd.8b00096 David L. Hughes 1
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1021/acs.oprd.8b00096 David L. Hughes 1
Affiliation
Enantioselective organocatalytic reactions published in the recent patent literature are highlighted in this review and include inter- and intramolecular phase-transfer conjugate additions catalyzed by quaternized cinchona alkaloids, a Diels–Alder reaction catalyzed by oxazaborolidine complexes, asymmetric Betti reactions, the Lonza synthesis of l-carnitine, and several Corey–Bakshi–Shibata reductions.
中文翻译:
药物开发中的不对称有机催化-最新专利文献的亮点
该综述着重介绍了近期专利文献中公开的对映选择性有机催化反应,包括季铵化金鸡纳生物碱催化的分子间和分子内相转移共轭物的加成,恶唑硼烷配合物催化的狄尔斯-阿尔德反应,不对称的贝蒂反应,Lonza合成l -肉碱,和几次Corey-Bakshi-Shibata减量。
更新日期:2018-04-19
中文翻译:
药物开发中的不对称有机催化-最新专利文献的亮点
该综述着重介绍了近期专利文献中公开的对映选择性有机催化反应,包括季铵化金鸡纳生物碱催化的分子间和分子内相转移共轭物的加成,恶唑硼烷配合物催化的狄尔斯-阿尔德反应,不对称的贝蒂反应,Lonza合成l -肉碱,和几次Corey-Bakshi-Shibata减量。