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Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2†
RSC Advances ( IF 3.9 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1039/c8ra02430h Chong Yan 1 , Weiyang Liu 1 , Jing Li 1 , Yanlian Deng 1 , Senhua Chen 2 , Hongju Liu 1
RSC Advances ( IF 3.9 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1039/c8ra02430h Chong Yan 1 , Weiyang Liu 1 , Jing Li 1 , Yanlian Deng 1 , Senhua Chen 2 , Hongju Liu 1
Affiliation
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Two new spiromeroterpenoids, namely fusariumin A (1) and B (2), along with four known terpenoids, asperterpenoid A (3), agathic acid (4), guignardone N (5), and trametenolic acid (6), were obtained from the endophytic fungus Fusarium sp. YD-2, derived from the twigs of Santalum album. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction using Cu Kα radiation, and that of 2 was elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited moderate anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with an IC50 value of 50 μM, and compound 3 showed strong anti-inflammatory activity with an IC50 value of 1.6 μM. In the antibacterial assay, compound 1 displayed significant activities against Staphylococcus aureus and Pseudomonas aeruginosa with an MIC value of 6.3 μg mL−1, and compound 3 showed moderate activities against Salmonella enteritidis and Micrococcus luteus with MIC values of 6.3 and 25.2 μg mL−1, respectively.
中文翻译：
来自檀香属植物的内生真菌镰刀菌属的生物活性萜类化合物。YD-2†
两种新的螺旋体萜类化合物，即镰刀菌素 A ( 1 ) 和 B ( 2 )，以及四种已知的萜类化合物，即 asperterpenoid A ( 3 )、agathic acid ( 4 )、guignardone N ( 5 ) 和曲美烯酸 ( 6 )，均来自内生真菌镰刀菌属。YD-2，来源于Santalum专辑的树枝。结合光谱分析阐明了它们的结构。1的绝对构型是通过使用 Cu Kα 辐射的单晶 X 射线衍射确定的，而2的绝对构型是在实验和计算的电子圆二色光谱的基础上阐明了。化合物2通过抑制脂多糖活化的RAW264.7细胞中一氧化氮（NO）的产生而表现出中等的体外抗炎活性，IC 50值为50 μM，化合物3表现出强抗炎活性，IC 50值为1.6微米。在抗菌试验中，化合物1对金黄色葡萄球菌和铜绿假单胞菌表现出显着活性，MIC值为6.3 μg mL -1，化合物3对金黄色葡萄球菌和铜绿假单胞菌表现出中等活性。肠炎沙门氏菌和黄体微球菌的 MIC 值分别为 6.3 和 25.2 μg mL -1。
更新日期：2018-04-19
中文翻译：
来自檀香属植物的内生真菌镰刀菌属的生物活性萜类化合物。YD-2†
两种新的螺旋体萜类化合物，即镰刀菌素 A ( 1 ) 和 B ( 2 )，以及四种已知的萜类化合物，即 asperterpenoid A ( 3 )、agathic acid ( 4 )、guignardone N ( 5 ) 和曲美烯酸 ( 6 )，均来自内生真菌镰刀菌属。YD-2，来源于Santalum专辑的树枝。结合光谱分析阐明了它们的结构。1的绝对构型是通过使用 Cu Kα 辐射的单晶 X 射线衍射确定的，而2的绝对构型是在实验和计算的电子圆二色光谱的基础上阐明了。化合物2通过抑制脂多糖活化的RAW264.7细胞中一氧化氮（NO）的产生而表现出中等的体外抗炎活性，IC 50值为50 μM，化合物3表现出强抗炎活性，IC 50值为1.6微米。在抗菌试验中，化合物1对金黄色葡萄球菌和铜绿假单胞菌表现出显着活性，MIC值为6.3 μg mL -1，化合物3对金黄色葡萄球菌和铜绿假单胞菌表现出中等活性。肠炎沙门氏菌和黄体微球菌的 MIC 值分别为 6.3 和 25.2 μg mL -1。
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