Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes†,Materials Horizons

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Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes†
Materials Horizons ( IF 12.2 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1039/c8mh00302e
Marta Mon _{1,

2,

3,

4,

5} , Rosaria Bruno _{6,

7,

8,

9} , Jesús Ferrando-Soria _{1,

2,

3,

4,

5} , Lucia Bartella _{6,

7,

8,

9} , Leonardo Di Donna _{6,

7,

8,

9} , Marianna Talia _{7,

9,

10,

11} , Rosamaria Lappano _{7,

9,

10,

11} , Marcello Maggiolini _{7,

9,

10,

11} , Donatella Armentano _{6,

7,

8,

9} , Emilio Pardo _{1,

2,

3,

4,

5}

Affiliation

We report a novel metal–organic framework (MOF) featuring functional pores decorated with hydroxyl groups derived from the natural amino acid L-serine, which is able to establish specific interactions of different natures, strengths and directionalities with organic molecules of technological interest, i.e. ascorbic acid, pyridoxine, bupropion and 17-β-estradiol, based on their different sizes and chemical natures. The ability of 1 to distinctly organize guest molecules within its channels, through the concomitant effect of different directing supramolecular host–guest interactions, enables gaining unique insights, by means of single-crystal X-ray crystallography, into the host–guest interactions. These results increase our understanding of molecular recognition processes in MOFs, opening a myriad of potential technological applications in the near future.

中文翻译：

药物@金属-有机框架中宿主与客体相互作用的晶体学快照：模拟分子识别过程†

我们报告一个新的金属-有机骨架（MOF），具有装饰有天然氨基酸衍生的羟基基团的官能毛孔大号-丝氨酸，其能够建立不同的性质，强度和方向性随着技术的兴趣，有机分子的特异性相互作用，即抗坏血酸，吡ido醇，安非他酮和17-β-雌二醇，基于其不同的大小和化学性质。1的能力通过不同的超分子主体－客体相互作用的伴随作用，在其通道内清晰地组织客体分子，使得能够通过单晶X射线晶体学获得对主体－客体相互作用的独特见解。这些结果加深了我们对MOF中分子识别过程的理解，并在不久的将来开启了众多潜在的技术应用。

更新日期：2018-04-19

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