当前位置: X-MOL 学术Mater. Horiz. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes†
Materials Horizons ( IF 12.2 ) Pub Date : 2018-04-19 00:00:00 , DOI: 10.1039/c8mh00302e
Marta Mon 1, 2, 3, 4, 5 , Rosaria Bruno 6, 7, 8, 9 , Jesús Ferrando-Soria 1, 2, 3, 4, 5 , Lucia Bartella 6, 7, 8, 9 , Leonardo Di Donna 6, 7, 8, 9 , Marianna Talia 7, 9, 10, 11 , Rosamaria Lappano 7, 9, 10, 11 , Marcello Maggiolini 7, 9, 10, 11 , Donatella Armentano 6, 7, 8, 9 , Emilio Pardo 1, 2, 3, 4, 5
Affiliation  

We report a novel metal–organic framework (MOF) featuring functional pores decorated with hydroxyl groups derived from the natural amino acid L-serine, which is able to establish specific interactions of different natures, strengths and directionalities with organic molecules of technological interest, i.e. ascorbic acid, pyridoxine, bupropion and 17-β-estradiol, based on their different sizes and chemical natures. The ability of 1 to distinctly organize guest molecules within its channels, through the concomitant effect of different directing supramolecular host–guest interactions, enables gaining unique insights, by means of single-crystal X-ray crystallography, into the host–guest interactions. These results increase our understanding of molecular recognition processes in MOFs, opening a myriad of potential technological applications in the near future.

中文翻译:

药物@金属-有机框架中宿主与客体相互作用的晶体学快照:模拟分子识别过程

我们报告一个新的金属-有机骨架(MOF),具有装饰有天然氨基酸衍生的羟基基团的官能毛孔大号-丝氨酸,其能够建立不同的性质,强度和方向性随着技术的兴趣,有机分子的特异性相互作用,即抗坏血酸,吡ido醇,安非他酮和17-β-雌二醇,基于其不同的大小和化学性质。1的能力通过不同的超分子主体-客体相互作用的伴随作用,在其通道内清晰地组织客体分子,使得能够通过单晶X射线晶体学获得对主体-客体相互作用的独特见解。这些结果加深了我们对MOF中分子识别过程的理解,并在不久的将来开启了众多潜在的技术应用。
更新日期:2018-04-19
down
wechat
bug