A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound-driven piezoelectric nanoparticle-assisted stimulation significantly reduced the proliferation by inducing the cell cycle arrest. Similarly to a low-intensity alternating electric field, chronic piezoelectric stimulation resulted able to inhibit cancer cell proliferation by upregulating the expression of the gene encoding Kir3.2 inward rectifier potassium channels, by interfering on Ca²⁺ homeostasis, and by affecting the organization of mitotic spindles during mitosis. The proposed platform, even if specific for HER2-positive cells, shows huge potential and versatility for the treatment of different type of cancers.

中文翻译：

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超声激活的压电纳米粒子抑制乳腺癌细胞的增殖。

提出了一种基于纳米技术的抑制乳腺癌细胞增殖的方法。该创新解决方案包含一个基于生物相容性压电纳米粒子的平台，该平台能够靶向并远程刺激HER2阳性乳腺癌细胞。超声驱动的压电纳米粒子辅助刺激的抗增殖作用通过诱导细胞周期停滞而显着降低了增殖。与低强度交流电场相似，慢性压电刺激通过干扰Ca ²⁺，可通过上调编码Kir3.2内向整流钾通道的基因的表达来抑制癌细胞的增殖。稳态，并通过影响有丝分裂期间有丝分裂纺锤体的组织。所提出的平台，即使特异于HER2阳性细胞，也显示出了治疗各种类型癌症的巨大潜力和多功能性。