Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8,ACS Chemical Neuroscience

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Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-04-18 00:00:00 , DOI: 10.1021/acschemneuro.8b00074
Li Gao ₁ , Jiaqi Li _{1,

2} , Yuzhi Zhou ₁ , Xudong Huang ₃ , Xuemei Qin ₁ , Guanhua Du _{1,

4}

Affiliation

Baicalein, a flavonoid derived from the roots of Scutellariae baicalensis Georgi, has shown health benefits for an array of human diseases including dementia. The senescence-accelerated mouse prone 8 (SAMP8) strain is extensively used as a senile dementia model. To further investigate the effects of baicalein in SAMP8 mice, behavioral testing, biochemical detection, and gut microbiota analysis were performed. The results demonstrated that treatment with baicalein ameliorated the senescence status of the SAMP8 mice, as manifested by reducing the grading score of senescence. Additionally, baicalein improved the cognitive functions of the SAMP8 mice, including spatial learning and memory abilities, object recognition memory, and olfactory memory. Furthermore, baicalein significantly inhibited the release of proinflammatory cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-α (TNF-α) in the brain cortex of SAMP8 mice. Gut microbiota analysis revealed that treatment with baicalein markedly altered the abundance of six genera in SAMP8 mice. Correlation analysis indicated that the abundances of Mucispirillum, Bacteroides, and Sutterella were negatively correlated with cognitive abilities and that Christensenellaceae was positively correlated with cognition. Furthermore, the abundance of Christensenellaceae was negatively correlated with the levels of IL-6 and TNF-α, while [Prevotella] was positively correlated with the levels of IL-1β and IL-6. In addition, Mucispirillum and Bacteroides were positively correlated with the level of IL-6 in the brain cortex. These data indicated that baicalein ameliorates senescence status and improves cognitive function in SAMP8 mice and that this effect might be attributable to suppression of cortical proinflammatory cytokines and modulation of the intestinal microbiome.

中文翻译：

黄ical素对衰老加速小鼠易发生的皮质促炎细胞因子和肠道微生物组的影响8

黄ical素，一种从黄the根中提取的黄酮类化合物乔治（Georgi）对包括痴呆症在内的多种人类疾病均显示出健康益处。衰老加速的小鼠俯卧8（SAMP8）菌株被广泛用作老年痴呆症模型。为了进一步研究黄ical素在SAMP8小鼠中的作用，进行了行为测试，生化检测和肠道菌群分析。结果表明，用黄ical素治疗改善了SAMP8小鼠的衰老状态，这通过降低衰老的评分来证明。此外，黄ical素改善了SAMP8小鼠的认知功能，包括空间学习和记忆能力，物体识别记忆和嗅觉记忆。此外，黄ical素显着抑制促炎细胞因子的释放，例如白介素6（IL-6），白介素1 beta（IL-1β），SAMP8小鼠大脑皮质中的肿瘤坏死因子-α（TNF-α）。肠道菌群分析显示，用黄ical素处理可显着改变SAMP8小鼠中6个属的丰度。相关分析表明粘螺旋藻，拟杆菌和Sutterella与认知能力呈负相关，而Christensenellaceae与认知呈正相关。此外，Christensenellaceae的丰度与IL-6和TNF-α呈负相关，而[ Prevotella ]与IL-1β和IL-6呈正相关。此外，粘螺旋藻和拟杆菌与大脑皮层IL-6水平呈正相关。这些数据表明黄ical素改善了SAMP8小鼠的衰老状态并改善了其认知功能，并且这种作用可能归因于皮质促炎细胞因子的抑制和肠道微生物组的调节。

更新日期：2018-04-18

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