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New highlights on the health-improving effects of sulforaphane
Food & Function ( IF 5.1 ) Pub Date : 2018-04-18 00:00:00 , DOI: 10.1039/c8fo00018b Alfredo Briones-Herrera 1, 2, 3, 4, 5 , Dianelena Eugenio-Pérez 1, 2, 3, 4, 5 , Jazmin Gabriela Reyes-Ocampo 1, 2, 3, 4, 5 , Susana Rivera-Mancía 5, 6, 7 , José Pedraza-Chaverri 1, 2, 3, 4, 5
Food & Function ( IF 5.1 ) Pub Date : 2018-04-18 00:00:00 , DOI: 10.1039/c8fo00018b Alfredo Briones-Herrera 1, 2, 3, 4, 5 , Dianelena Eugenio-Pérez 1, 2, 3, 4, 5 , Jazmin Gabriela Reyes-Ocampo 1, 2, 3, 4, 5 , Susana Rivera-Mancía 5, 6, 7 , José Pedraza-Chaverri 1, 2, 3, 4, 5
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In this paper, we review recent evidence about the beneficial effects of sulforaphane (SFN), which is the most studied member of isothiocyanates, on both in vivo and in vitro models of different diseases, mainly diabetes and cancer. The role of SFN on oxidative stress, inflammation, and metabolism is discussed, with emphasis on those nuclear factor E2-related factor 2 (Nrf2) pathway-mediated mechanisms. In the case of the anti-inflammatory effects of SFN, the point of convergence seems to be the downregulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), with the consequent amelioration of other pathogenic processes such as hypertrophy and fibrosis. We emphasized that SFN shows opposite effects in normal and cancer cells at many levels; for instance, while in normal cells it has protective actions, in cancer cells it blocks the induction of factors related to the malignity of tumors, diminishes their development, and induces cell death. SFN is able to promote apoptosis in cancer cells by many mechanisms, the production of reactive oxygen species being one of the most relevant ones. Given its properties, SFN could be considered as a phytochemical at the forefront of natural medicine.
中文翻译：
萝卜硫烷对健康改善作用的新亮点
在本文中，我们回顾了有关异硫氰酸酯研究最多的萝卜硫烷（SFN）对体内和体外的有益作用的最新证据。不同疾病的模型，主要是糖尿病和癌症。讨论了SFN在氧化应激，炎症和代谢中的作用，并着重于那些核因子E2相关因子2（Nrf2）途径介导的机制。就SFN的抗炎作用而言，收敛点似乎是活化B细胞的核因子κ轻链增强子（NF-κB）的下调，从而改善了其他致病过程例如肥大和纤维化。我们强调，SFN在正常细胞和癌细胞中显示出相反的作用。例如，在正常细胞中它具有保护作用，而在癌细胞中，它阻止与肿瘤恶性相关的因子的诱导，减少其发展并诱导细胞死亡。SFN能够通过多种机制促进癌细胞的凋亡，其中活性氧的产生是最相关的一种。鉴于其特性，SFN可以被认为是天然药物最前沿的植物化学。
更新日期：2018-04-18
中文翻译：
萝卜硫烷对健康改善作用的新亮点
在本文中，我们回顾了有关异硫氰酸酯研究最多的萝卜硫烷（SFN）对体内和体外的有益作用的最新证据。不同疾病的模型，主要是糖尿病和癌症。讨论了SFN在氧化应激，炎症和代谢中的作用，并着重于那些核因子E2相关因子2（Nrf2）途径介导的机制。就SFN的抗炎作用而言，收敛点似乎是活化B细胞的核因子κ轻链增强子（NF-κB）的下调，从而改善了其他致病过程例如肥大和纤维化。我们强调，SFN在正常细胞和癌细胞中显示出相反的作用。例如，在正常细胞中它具有保护作用，而在癌细胞中，它阻止与肿瘤恶性相关的因子的诱导，减少其发展并诱导细胞死亡。SFN能够通过多种机制促进癌细胞的凋亡，其中活性氧的产生是最相关的一种。鉴于其特性，SFN可以被认为是天然药物最前沿的植物化学。
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