Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet†,Food & Function

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Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet†
Food & Function ( IF 5.1 ) Pub Date : 2018-04-18 00:00:00 , DOI: 10.1039/c8fo00355f
Xavier Escoté _{1,

2,

3,

4,

5} , Elisa Félix-Soriano _{1,

2,

3,

4,

5} , Lucía Gayoso _{1,

2,

3,

4,

5} , Ana Elsa Huerta _{1,

2,

3,

4,

5} , María Antonella Alvarado _{1,

2,

3,

4,

5} , Diana Ansorena _{1,

2,

3,

4,

5} , Iciar Astiasarán _{1,

2,

3,

4,

5} , J. Alfredo Martínez _{1,

2,

3,

4,

5} , María Jesús Moreno-Aliaga _{1,

2,

3,

4,

5}

Affiliation

FGF21 has emerged as a key metabolism and energy homeostasis regulator. Dietary supplementation with eicosapentaenoic acid (EPA) and/or α-lipoic acid (LIP) has shown beneficial effects on obesity. In this study, we evaluated EPA and/or LIP effects on plasma FGF21 and the fatty acid (FA) profile in overweight/obese women following hypocaloric diets. At the baseline, FGF21 levels were negatively related to the AST/ALT ratio and HMW adiponectin. The weight loss did not cause any significant changes in FGF21 levels, but after the intervention FGF21 increased in EPA-supplemented groups compared to non-EPA-supplemented groups. EPA supplementation decreased the plasma n-6-PUFA content and increased n-3-PUFAs, mainly EPA and DPA, but not DHA. In the LIP-alone supplemented group a decrease in the total SFA and n-6-PUFA content was observed after the supplementation. Furthermore, EPA affected the desaturase activity, lowering Δ4D and raising Δ5/6D. These effects were not observed in the LIP-supplemented groups. Besides, the changes in FGF21 levels were associated with the changes in EPA, n-3-PUFAs, Δ5/6D, and n-6/n-3 PUFA ratio. Altogether, our study suggests that n-3-PUFAs influence FGF21 levels in obesity, although the specific mechanisms implicated remain to be elucidated.

中文翻译：

摄入低热量饮食后，EPA和硫辛酸补充对超重/肥胖女性循环FGF21和脂肪酸谱的影响†

FGF21已成为关键的新陈代谢和能量稳态调节剂。膳食补充二十碳五烯酸（EPA）和/或α-硫辛酸（LIP）已显示出对肥胖的有益作用。在这项研究中，我们评估了低热量饮食对超重/肥胖妇女血浆EPA21和/或LIP对血浆FGF21和脂肪酸（FA）的影响。在基线时，FGF21水平与AST / ALT比和HMW脂联素呈负相关。体重减轻并未引起FGF21水平的任何显着变化，但是在干预后，与未补充EPA的组相比，在补充EPA的组中FGF21增加。EPA补充降低血浆n-6-PUFA含量，增加n-3-PUFA，主要是EPA和DPA，但不增加DHA。在仅LIP的补充组中，补充后观察到总SFA和n-6-PUFA含量降低。此外，EPA影响了去饱和酶的活性，降低了Δ4D并提高了Δ5/ 6D。在LIP补充组中未观察到这些效果。此外，FGF21水平的变化与EPA，n-3-PUFA，Δ5/ 6D和n-6 / n-3 PUFA比的变化有关。总体而言，我们的研究表明，尽管肥胖的相关机制尚待阐明，但n-3-PUFAs会影响肥胖症患者FGF21的水平。

更新日期：2018-04-18

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